{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:23Z","timestamp":1786977503006,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Charcot neuroarthropathy (CN) is a disabling complication, culminating in bone destruction and involving joints and articular cartilage with high inflammatory environment. Its real pathogenesis is as yet unknown. In autoinflammatory diseases, such as rheumatoid arthritis, characterized by inflammation and joint involvement, autoantibodies against oxidative post\u2010translationally modified (oxPTM) collagen type I (CI) and type II (CII) were detected. Therefore, the aim of our study was to assess the potential involvement of autoimmunity in charcot neuroarthropathy, investigating the presence of autoantibodies oxPTM\u2010CI and oxPTM\u2010CII, in participants with charcot neuroarthropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this case\u2010control study, we enrolled 124 participants with type 2 diabetes mellitus (47 with charcot neuroarthropathy, 37 with diabetic peripheral neuropathy without charcot neuroarthropathy, and 40 with uncomplicated diabetes), and 32 healthy controls. The CI and CII were modified with ribose and other oxidant species, and the modifications were evaluated with sodium dodecyl sulfate\u2010polyacrylamide gel electrophoresis. Binding of sera from the participants was analyzed with enzyme\u2010linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Age, body mass index, waist and hip circumferences, and lipid profile were similar across the 4 groups, as well as glycated hemoglobin and duration of diabetes among people with diabetes. An increased binding to both native and all oxidation\u2010modified forms of CII was found in participants with CN and diabetic neuropathy. Conversely, for CI, an aspecific increased reactivity was noted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results detected the presence of autoantibodies against oxidative post\u2010translational modified collagen, particularly type 2 collagen, in participants with charcot neuroarthropathy and diabetic neuropathy, suggesting the possible involvement of autoimmunity. Further studies are required to understand the role of autoimmunity in the pathogenesis of charcot neuroarthropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.2839","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T14:46:46Z","timestamp":1469458006000},"source":"Crossref","is-referenced-by-count":17,"title":["Autoantibodies to post\u2010translationally modified type I and II collagen in Charcot neuroarthropathy in subjects with type 2 diabetes mellitus"],"prefix":"10.1002","volume":"33","author":[{"given":"Paola","family":"Rizzo","sequence":"first","affiliation":[{"name":"Diabetes Care Unit, Internal Medicine University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"},{"name":"Centre for Biochemical Pharmacology, William Harvey Research Institute Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Pitocco","sequence":"additional","affiliation":[{"name":"Diabetes Care Unit, Internal Medicine University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Zaccardi","sequence":"additional","affiliation":[{"name":"Diabetes Care Unit, Internal Medicine University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Di Stasio","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocky","family":"Strollo","sequence":"additional","affiliation":[{"name":"Centre for Biochemical Pharmacology, William Harvey Research Institute Queen Mary University of London  London UK"},{"name":"Department of Endocrinology &amp; Diabetes, Campus Bio\u2010Medico University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rizzi","sequence":"additional","affiliation":[{"name":"Diabetes Care Unit, Internal Medicine University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Scavone","sequence":"additional","affiliation":[{"name":"Diabetes Care Unit, Internal Medicine University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Costantini","sequence":"additional","affiliation":[{"name":"Diabetes Care Unit, Internal Medicine University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Galli","sequence":"additional","affiliation":[{"name":"Institute of Orthopedic Surgery University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Tinelli","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Flex","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Caputo","sequence":"additional","affiliation":[{"name":"Diabetes Care Unit, Internal Medicine University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pozzilli","sequence":"additional","affiliation":[{"name":"Department of Endocrinology &amp; Diabetes, Campus Bio\u2010Medico University of Rome  Rome Italy"},{"name":"Centre for Diabetes Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Landolfi","sequence":"additional","affiliation":[{"name":"Institute of Internal Medicine University Hospital \u201cA. Gemelli\u201d, Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Ghirlanda","sequence":"additional","affiliation":[{"name":"Diabetes Care Unit, Internal Medicine University Hospital \u201cA. 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