{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:04:19Z","timestamp":1784297059493,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["G061895"],"award-info":[{"award-number":["G061895"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0001164"],"award-info":[{"award-number":["G0001164"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is unclear whether cardiovascular risk factor modification influences the development of renal disease in people with type 2 diabetes identified through screening. We determined predictors of albuminuria 5\u00a0years after a diagnosis of screen\u2010detected diabetes within the ADDITION\u2010Europe study, a pragmatic cardiovascular outcome trial of multifactorial cardiovascular risk management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 1826 participants with newly diagnosed, screen\u2010detected diabetes without albuminuria, we explored associations between risk of new albuminuria (\u22652.5\u00a0mg\u00a0mmol<jats:sup>\u20101<\/jats:sup> for males and \u22653.5\u00a0mg\u00a0mmol<jats:sup>\u20101<\/jats:sup> for females) and (1) baseline cardio\u2010metabolic risk factors and (2) changes from baseline to 1\u00a0year in systolic blood pressure (\u0394SBP) and glycated haemoglobin (\u0394HbA<jats:sub>1c<\/jats:sub>) using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Albuminuria developed in 268 (15%) participants; baseline body mass index and active smoking were independently associated with new onset albuminuria in 5\u00a0years after detection of diabetes. In a model adjusted for age, gender, baseline HbA<jats:sub>1c<\/jats:sub> and blood pressure, a 1% decrease in HbA<jats:sub>1c<\/jats:sub> and 5\u2010mm\u00a0Hg decrease in SBP during the first year were independently associated with lower risks of albuminuria (odds ratio), 95% confidence interval: 0.76, 0.62 to 0.91 and 0.94, 0.88 to 1.01, respectively. Further adjustment did not materially change these estimates. There was no interaction between \u0394SBP and \u0394HbA<jats:sub>1c<\/jats:sub> in relation to albuminuria risk, suggesting likely additive effects on renal microvascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Baseline measurements and changes in HbA<jats:sub>1c<\/jats:sub> and SBP a year after diagnosis of diabetes through screening independently associate with new onset albuminuria 4\u00a0years later. Established multifactorial treatment for diabetes applies to cases identified through screening.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2877","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T10:43:01Z","timestamp":1482921781000},"source":"Crossref","is-referenced-by-count":3,"title":["Cardiovascular risk factors and incident albuminuria in screen\u2010detected type 2 diabetes"],"prefix":"10.1002","volume":"33","author":[{"given":"D.R.","family":"Webb","sequence":"first","affiliation":[{"name":"Diabetes Research Centre University of Leicester, Leicester General Hospital  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zaccardi","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester, Leicester General Hospital  Leicester 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