{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:08:25Z","timestamp":1769213305815,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Israel Science Foundation, the Deutsche, Forschungsgemeinschaft (DFG)","award":["SFB1052"],"award-info":[{"award-number":["SFB1052"]}]},{"name":"Israeli Ministry of Science and Technology","award":["3-13604"],"award-info":[{"award-number":["3-13604"]}]},{"name":"Dr Robert C. and Veronica Atkins Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intrahepatic fat (IHF) is best known to associate with waist circumference (WC) and visceral adipose tissue (VAT), but its relation to abdominal subcutaneous adipose tissue is controversial. While IHF\u00a0\u2265\u00a05% dichotomously defines fatty liver, %IHF is rarely considered as a continuous variable that includes the normal range. In this study, we aimed to evaluate %IHF association with abdominal fat subdepots, pancreatic, and renal\u2010sinus fats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated %IHF, abdominal fat subdepots, %pancreatic, and renal\u2010sinus fats, among individuals with moderate abdominal obesity, using 3\u2010Tesla magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 275 participants, %IHF widely ranged (0.01%\u201050.4%) and was lower in women (1.6%) than men (7.3%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). In an age, sex, and WC\u2010adjusted models, VAT area (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.006) was directly associated with %IHF, while superficial\u2013subcutaneous adipose tissue proportion was inversely associated with %IHF (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.006). In these models, renal\u2010sinus fat was positively associated with %IHF (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005). In an age, sex, WC, and VAT\u2010adjusted models, elevated liver enzymes, glycemic, lipid, and inflammatory biomarkers were associated with increased %IHF (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.003 for all). In these models, the associations remained robust even within the normal range strata of IHF\u00a0&lt;\u00a05% for triglycerides and chemerin (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.004 for all). For the diagnosis of fatty liver, the joint area under the curve of WC, alanine\u2010aminotransferase, triglycerides\/high\u2010density lipoprotein cholesterol, and homeostasis model assessment of insulin resistance was 0.84(95% CI, 0.79\u20100.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intrahepatic fat is differentially associated with abdominal fat subdepots. Intrahepatic\u2010fat as a continuous variable could be predicted by specific traditional parameters, even within the current normal range, and partially independent of VAT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2888","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T03:46:42Z","timestamp":1487130402000},"source":"Crossref","is-referenced-by-count":16,"title":["Intrahepatic fat, abdominal adipose tissues, and metabolic state: magnetic resonance imaging study"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-3751","authenticated-orcid":false,"given":"Anat","family":"Yaskolka Meir","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer\u2010Sheva 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