{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:18:40Z","timestamp":1773911920926,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["91110030"],"award-info":[{"award-number":["91110030"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Advanced glycation end\u2010products are a heterogeneous group of molecules that are formed during reactions between reducing sugars and proteins. Advanced glycation end\u2010products are thought to play a role in several diseases, including diabetes mellitus and can be measured non\u2010invasively using skin autofluorescence (AF). The aim of this cross\u2010sectional study was to investigate associations between skin AF and cardio\u2010metabolic, lifestyle, and dietary factors within a general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The NQplus study is an ongoing longitudinal study in the surroundings of Wageningen, the Netherlands. In this cross\u2010sectional study, skin AF was measured in 957 participants, aged 20 to 77\u00a0years, with the AGE Reader. Logistic regression was used to assess associations between skin AF and the following factors: demographics, adiposity, blood lipids, fasting glucose, HbA<jats:sub>1c<\/jats:sub>, blood pressure, dietary intake, and disease history. Stepwise linear regression was used to identify factors correlating with skin AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In males, skin AF was significantly associated with age, coffee intake, systolic and diastolic blood pressure, body fat, full fat dairy, and educational level. In females, significant associations were found with age, coffee intake, HbA<jats:sub>1c<\/jats:sub>, diabetes, and eGFR. In the total population, current smoking was positively associated with skin AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This cross\u2010sectional study in a general population showed that age and coffee intake were associated with skin AF in both males and females. We observed a gender disparity for some of the associations with skin AF, which need to be confirmed by further research. More detailed research is needed to assess the association between skin AF and diet.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2892","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T21:16:42Z","timestamp":1488403002000},"source":"Crossref","is-referenced-by-count":23,"title":["Advanced glycation end\u2010products (<scp>AGEs<\/scp>) and associations with cardio\u2010metabolic, lifestyle, and dietary factors in a general population: the <scp>NQplus<\/scp> study"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9694-5946","authenticated-orcid":false,"given":"Nadia","family":"Botros","sequence":"first","affiliation":[{"name":"Division of Human Nutrition Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diewertje","family":"Sluik","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"van Waateringe","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Groningen, University Medical Center Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne H.M.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouk","family":"Geelen","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith J.M.","family":"Feskens","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition Wageningen University &amp; Research  Wageningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6779377"},{"key":"e_1_2_7_3_1","first-page":"66","article-title":"Action of amino acids on sugars. 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