{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:09:38Z","timestamp":1773306578771,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000329","name":"Novo Nordisk UK Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Evidence links the lectin pathway of complement activation to diabetic kidney disease. Upon carbohydrate\u2010recognition by pattern\u2010recognition molecules, eg, mannan\u2010binding lectin (MBL), the MBL\u2010associated serine protease (MASP\u20102) is activated and initiates the complement cascade. The <jats:italic>MASP2<\/jats:italic> gene encodes MASP\u20102 and the alternative splice product MBL\u2010associated protein 19 (MAp19). Both MAp19 and MASP\u20102 circulate in complex with MBL. We tested the hypothesis that MAp19 and MASP\u20102 concentrations predict the risk of incident microalbuminuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline MAp19 and MASP\u20102 were measured in 270 persons with newly diagnosed type 1 diabetes tracked for incidence of persistent microalbuminuria in a prospective observational 18\u2010year\u2010follow\u2010up study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010five participants (28%) developed microalbuminuria during follow\u2010up. MBL\u2010associated protein 19 concentrations were higher in participants that later progressed to microalbuminuria as compared with those with persistent normoalbuminuria (268\u00a0ng\/mL [95% CI, 243\u2010293] vs 236\u00a0ng\/mL [95% CI, 223\u2010250], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). Participants with MAp19 concentration within the highest quartile of the cohort had an increased risk of microalbuminuria as compared with participants with MAp19 concentration within the combined lower 3 quartiles in unadjusted Cox analysis, hazard ratio 1.86 ([95% CI, 1.17\u20102.96], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.009). This remained significant in adjusted models, eg, adjusting for age, sex, HbA<jats:sub>1c<\/jats:sub>, systolic blood pressure, urinary albumin excretion, smoking, serum creatinine, and serum cholesterol. MBL\u2010associated serine protease concentration was not associated with incidence of microalbuminuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, the results show an association between baseline MAp19 concentration and the incidence of microalbuminuria in an 18\u2010year\u2010follow\u2010up study on persons with newly diagnosed type 1 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2895","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T04:17:01Z","timestamp":1489724221000},"source":"Crossref","is-referenced-by-count":6,"title":["Incident microalbuminuria and complement factor mannan\u2010binding lectin\u2010associated protein 19 in people with newly diagnosed type 1 diabetes"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9877-5327","authenticated-orcid":false,"given":"J.A.","family":"\u00d8stergaard","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital and Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"},{"name":"The Danish Diabetes Academy  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-155X","authenticated-orcid":false,"given":"S.","family":"Thiel","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5844-4304","authenticated-orcid":false,"given":"I.T.","family":"Hoffmann\u2010Petersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital and Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5630-5055","authenticated-orcid":false,"given":"P.","family":"Hovind","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010H.","family":"Parving","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8735-966X","authenticated-orcid":false,"given":"L.","family":"Tarnow","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center  Gentofte Denmark"},{"name":"Nordsj\u00e6llands Hospital  Hiller\u00f8d Denmark"},{"name":"Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-4294","authenticated-orcid":false,"given":"P.","family":"Rossing","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center  Gentofte Denmark"},{"name":"Faculty of Health Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-2868","authenticated-orcid":false,"given":"T.K.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital and Department of Clinical Medicine, Faculty of Health Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2014.03.009"},{"key":"e_1_2_7_3_1","unstructured":"System URD. U.S. Renal Data System USRDS.Annual data report: atlas of chronic kidney disease and end\u2010stage renal disease in the United States National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases 2013.http:\/\/www.usrds.org\/2013\/pdf\/v2_ch1_13.pdf. 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