{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:13:22Z","timestamp":1782180802206,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Grants Council Theme-based Research Scheme","award":["T12-402\/13-N"],"award-info":[{"award-number":["T12-402\/13-N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infection occurs more commonly in diabetic patients compared with the general population and is an under\u2010recognised but important morbidity in patients with diabetes. We examined the impact of glycaemic control on hospitalisation for infection in a large prospective cohort of Chinese adults with type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between July 1994 and June 2014, 22\u00a0846 patients with type 2 diabetes underwent detailed assessment of metabolic control and diabetes complications. Patients were followed for occurrence of infection requiring hospitalisation as identified using discharge diagnosis codes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a median follow\u2010up of 4.8\u00a0years, 20.3% of patients were hospitalised for any infection type, with respiratory tract, genitourinary tract, and skin being the most commonly affected sites. In multivariate Cox regression, time\u2010dependent HbA1c was associated with all\u2010site infection (hazard ratio [HR] 1.07 [95% confidence interval {CI}:1.05\u20101.09, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001]), genitourinary tract infection (HR 1.09 [95% CI: 1.04\u20101.14], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and skin infection (HR 1.16 [95% CI 1.12\u20101.21]. <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), but not infection of respiratory tract, and was independent of age, gender, disease duration, smoking, body mass index, glomerular filtration rate, haemoglobin, history of stroke, congestive heart failure, coronary heart disease, peripheral artery disease, diabetic neuropathy and cancer, and baseline drug use. Against an arbitrary HbA1c interval of &gt;7.0\u20108.0% (53\u201064\u00a0mmol\/mol), patients with HbA1c \u22646.0% (42\u00a0mmol\/mol) and &gt;8.0% (64\u00a0mmol\/mol) had excess risks of infection\u2010related hospitalisation adjusted for other factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with type 2 diabetes, burden of serious infection is high. In the diabetic population, a U\u2010shape relationship between glycaemia and infection\u2010related hospitalisation was detected.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2923","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T11:28:46Z","timestamp":1500636526000},"source":"Crossref","is-referenced-by-count":28,"title":["Glycaemia control and the risk of hospitalisation for infection in patients with type 2 diabetes: Hong Kong Diabetes Registry"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-6069","authenticated-orcid":false,"given":"Andrea O.Y.","family":"Luk","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics  Hong Kong"},{"name":"Hong Kong Institute of Diabetes and Obesity  Hong Kong"},{"name":"Li Ka Shing Institute of Health Sciences  Hong Kong"},{"name":"Prince of Wales Hospital  Hong Kong SAR China"},{"name":"The Chinese University of Hong Kong  Hong Kong SAR 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