{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:15:09Z","timestamp":1780514109502,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetes is a serious disease with severe side effects and comorbidities. Diabetic foot with its chronic nonhealing ulcers, or diabetic foot ulcers, as they are commonly called, can be devastating, even leading to amputation. Many therapies exist to assist and improve wound healing. One exciting discovery is the use of negative pressure wound therapy (NPWT) as an adjunct to standard treatment. Few studies have substantively explored the molecular mechanisms of NPWT and why we see improved wound healing, a concept that demands more research. The following commentary summarizes the current literature regarding NPWT as well as some of the vast body of work that focuses on the physiologic mechanisms of wound healing in diabetics in general.<\/jats:p>","DOI":"10.1002\/dmrr.2929","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T14:12:39Z","timestamp":1502979159000},"source":"Crossref","is-referenced-by-count":32,"title":["Dysregulation of wound healing mechanisms in diabetes and the importance of negative pressure wound therapy (NPWT)"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-6211","authenticated-orcid":false,"given":"Mogher","family":"Khamaisi","sequence":"first","affiliation":[{"name":"Internal Medicine D and Institute of Endocrinology, Diabetes and Metabolism, Rambam Health Care Campus, Faculty of Medicine Technion\u2010Israel Institute of Technology  Haifa Israel"},{"name":"Institute of Endocrinology, Diabetes and Metabolism, Rambam Health Care Campus, Faculty of Medicine Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarit","family":"Balanson","sequence":"additional","affiliation":[{"name":"Internal Medicine D and Institute of Endocrinology, Diabetes and Metabolism, Rambam Health Care Campus, Faculty of Medicine Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"e_1_2_3_2_1","unstructured":"World Health Organization.Global report on diabetes. 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