{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:31:00Z","timestamp":1790368260803,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007505","name":"Kirsten og Freddy Johansens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gluten\u2010free (GF) diet during pregnancy ameliorates autoimmune diabetes in nonobese diabetic (NOD) mouse offspring. Due to comorbidity of celiac disease in type 1 diabetes, we hypothesized that GF diet in utero alleviates the humoral and histopathological signs of celiac disease in NOD mice. We aimed to establish the mechanisms behind the diabetes\u2010protective effect of GF diet in utero.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Breeding pairs of NOD mice were fed a GF or gluten\u2010containing standard (STD) diet until parturition. The offspring were nursed by mothers on STD diet and continued on this diet until ages 4 and 13\u00a0weeks. Analyses of serum antitissue transglutaminase (anti\u2010tTG) intestine and islet histology, islet transglutaminase (TG) activity, and cytokine expression in T cells from lymphoid organs were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GF versus STD diet in utero led to reduced serum anti\u2010tTG titre and increased villus\u2010to\u2010crypt ratio at both ages. Insulitis along with systemic and local inflammation were decreased, but islet TG activity was unchanged in 13\u2010week\u2010old GF mice. These mice had unchanged beta\u2010cell volumes, but increased islet numbers throughout the prediabetic period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Collectively, GF diet administered during pregnancy improves signs of celiac disease and autoimmune diabetes in the offspring. The diabetes\u2010ameliorative effect of GF diet in utero is followed by dampening of inflammation, unchanged beta\u2010cell volume, but increased islet numbers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.2987","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T08:52:36Z","timestamp":1517561556000},"source":"Crossref","is-referenced-by-count":13,"title":["Gluten\u2010free diet during pregnancy alleviates signs of diabetes and celiac disease in NOD mouse offspring"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-5862","authenticated-orcid":false,"given":"Martin","family":"Haupt\u2010Jorgensen","sequence":"first","affiliation":[{"name":"The Bartholin Institute Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Larsen","sequence":"additional","affiliation":[{"name":"The Bartholin Institute Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knud","family":"Josefsen","sequence":"additional","affiliation":[{"name":"The Bartholin Institute Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina Z.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"The Bartholin Institute Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie Christine","family":"Antvorskov","sequence":"additional","affiliation":[{"name":"The Bartholin Institute Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel K.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences University of Copenhagen  Frederiksberg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Buschard","sequence":"additional","affiliation":[{"name":"The Bartholin Institute Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-7560(199909\/10)15:5<323::AID-DMRR53>3.0.CO;2-P"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3047574"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807917"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri885"},{"issue":"3","key":"e_1_2_9_7_1","first-page":"1565","article-title":"Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non\u2010celiac gluten sensitivity","volume":"7","author":"Hollon J","year":"2015","journal-title":"Forum Nutr"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.9.5830"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045216"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1718-2"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0465-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.07.030"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1214"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-007-0517-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.068429"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.023"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.9.2287"},{"issue":"4","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2337\/diab.46.4.583","article-title":"Glutamate decarboxylase\u2010reactive peripheral blood lymphocytes from patients with IDDM express gut\u2010specific homing receptor alpha4beta7\u2010integrin","volume":"46","author":"Paronen J","year":"1997","journal-title":"Diabetes"},{"issue":"9","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2337\/diab.45.9.1173","article-title":"Mucosa\u2010associated (beta 7\u2010integrinhigh) lymphocytes accumulate early in the pancreas of NOD mice and show aberrant recirculation behavior","volume":"45","author":"Hanninen A","year":"1996","journal-title":"Diabetes"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2010.04.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118618"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12340"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344264"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033315"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12007"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1612"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2424306"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066474"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.6.697"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1987.tb02837.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2802"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1984.tb02501.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1986.tb02764.x"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.04.030"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2564-7"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078687"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019645"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1113"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.05.007"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045209"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118006"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.11.008"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9424"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0895(199612)12:4<341::AID-DMR173>3.0.CO;2-O"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043690"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)33642-0"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.7.1716"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.2987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.2987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:01:26Z","timestamp":1695495686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.2987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,15]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/dmrr.2987"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.2987","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,15]]},"article-number":"e2987"}}