{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:56:58Z","timestamp":1786481818139,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The diabetic foot syndrome (DFS) is a serious complication in patients with diabetes increasing the risk for minor\/major amputations. This analysis aimed to examine differences in diabetes patients with or without DFS stratified by type 1 (T1D) or type 2 diabetes (T2D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Adult patients (\u226520y of age) with diabetes from the German\/Austrian diabetes patients follow\u2010up registry (DPV) were included. The cross\u2010sectional study comprised 45\u00a0722 subjects with T1D (n<jats:sub>DFS<\/jats:sub>\u00a0=\u00a02966) and 313\u00a0264 with T2D (n<jats:sub>DFS<\/jats:sub>\u00a0=\u00a030\u00a0904). In DFS, minor\/major amputations were analysed. To compare HbA<jats:sub>1C<\/jats:sub>, neuropathy, nephropathy, cardiovascular disease risk factors, and macrovascular complications between patients with or without DFS, regression models were conducted. Confounders: age, sex, diabetes duration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with DFS, a minor amputation was documented in 27.2% (T1D) and 25.9% (T2D), a major amputation in 10.2% (T1D) and 11.3% (T2D). Regression models revealed that neuropathy was more frequent in subjects with DFS compared with patients without DFS (T1D: 70.7 vs 29.8%; T2D: 59.4% vs 36.9%; both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Hypertension, nephropathy, peripheral vascular disease, stroke, or myocardial infarction was more common compared with patients without DFS (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). In T1D with DFS, a slightly higher HbA<jats:sub>1C<\/jats:sub> (8.11% vs 7.95%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and in T2D with DFS a lower HbA<jats:sub>1C<\/jats:sub> (7.49% vs 7.69%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One third of the patients with DFS had an amputation of the lower extremity. Especially neuropathy or peripheral vascular disease was more prevalent in patients with DFS. New concepts to prevent DFS\u2010induced amputations and to reduce cardiovascular risk factors before the occurrence of DFS are necessary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3020","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T06:45:56Z","timestamp":1525416356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Diabetic foot syndrome in patients with diabetes. A multicenter German\/Austrian DPV analysis on 33\u00a0870 patients"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8363-943X","authenticated-orcid":false,"given":"Barbara","family":"Bohn","sequence":"first","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, ZIBMT University of Ulm  Ulm Germany"},{"name":"German Center for Diabetes Research (DZD)  Munich\u2010Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Gr\u00fcnerbel","sequence":"additional","affiliation":[{"name":"Specialized Practice for Diabetes and Nutritional Medicine  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Altmeier","sequence":"additional","affiliation":[{"name":"Diabetescenter, Klinikum Dortmund GmbH  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Giesche","sequence":"additional","affiliation":[{"name":"Clinic of Internal Medicine, Alexianer St. Hedwig Hospital  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pfeifer","sequence":"additional","affiliation":[{"name":"Diabetes Center, Clinic Tettnang  Tettnang Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wagner","sequence":"additional","affiliation":[{"name":"Specialized Diabetes Practice  Saaldorf\u2010Surheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Heise","sequence":"additional","affiliation":[{"name":"Alb Fils Kliniken, Helfenstein Clinic  Geislingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Best","sequence":"additional","affiliation":[{"name":"Diabetes\u2010Practice Dr. Best  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Fasching","sequence":"additional","affiliation":[{"name":"5<sup>th<\/sup> Medical Department, Wilhelminenspital  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard W.","family":"Holl","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, ZIBMT University of Ulm  Ulm Germany"},{"name":"German Center for Diabetes Research (DZD)  Munich\u2010Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060917"},{"key":"e_1_2_9_3_1","first-page":"83","volume-title":"Deutscher Gesundheitsbericht. 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