{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:44:19Z","timestamp":1790365459561,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity has been shown to trigger adaptive increases in pancreas parenchymal and fat volume. Consecutively, pancreatic steatosis may lead to beta\u2010cell dysfunction. However, it is not known whether the pancreatic tissue components decrease with weight loss and pancreatic steatosis is reversible following Roux\u2010en\u2010Y gastric bypass (RYGB). Therefore, the objective of the study was to investigate the effects of RYGB\u2010induced weight loss on pancreatic volume and glucose homeostasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven patients were recruited in the Obesity Centre of the University Medical Centre Hamburg\u2010Eppendorf. Before and 6\u00a0months after RYGB, total GLP\u20101 levels were measured during oral glucose tolerance test. To assess changes in visceral adipose tissue and pancreatic volume, MRI was performed. Measures of glucose homeostasis and insulin indices were assessed. Fractional beta\u2010cell area was estimated by correlation with the C\u2010peptide\u2010to\u2010glucose ratio; beta\u2010cell mass was calculated by the product of beta\u2010cell area and pancreas parenchymal weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pancreas volume decreased from 83.8 (75.7\u201092.0) to 70.5 (58.8\u201082.3) cm<jats:sup>3<\/jats:sup> (mean [95% CI], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). The decrease in total volume was associated with a significant decrease in fat volume. Fasting insulin and C\u2010peptide were lower post RYGB. HOMA\u2010IR levels decreased, whereas insulin sensitivity increased (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). This was consistent with a reduction in the estimated beta\u2010cell area and mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Following RYGB, pancreatic volume and steatosis adaptively decreased to \u201cnormal\u201d levels with accompanying improvement in glucose homeostasis. Moreover, obesity\u2010driven beta\u2010cell expansion seems to be reversible; however, future studies must define a method to more accurately estimate functional beta\u2010cell mass to increase our understanding of glucose homeostasis after RYGB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3025","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T23:05:34Z","timestamp":1526511934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Adaptive changes in pancreas post Roux\u2010en\u2010Y gastric bypass induced weight loss"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7763-1527","authenticated-orcid":false,"given":"A.","family":"Lautenbach","sequence":"first","affiliation":[{"name":"Department for Endocrinology and Diabetology University Medical Centre Hamburg\u2010Eppendorf  Hamburg 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