{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:33:40Z","timestamp":1763037220441,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["15411953100"],"award-info":[{"award-number":["15411953100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["20152232"],"award-info":[{"award-number":["20152232"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270397","81770802"],"award-info":[{"award-number":["81270397","81770802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between ankle\u2010branchial index (ABI) and cardiovascular disease in type 2 diabetes patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 634 inpatients with type 2 diabetes were recruited in this cross\u2010sectional study. All patients were measured with ABI and computed tomography angiography (CTA) scan for coronary artery disease (CAD). According to ABI values, patients were divided into three groups: low\u2010ABI group (ABI\u00a0&lt;\u00a00.9, n\u00a0=\u00a0259), normal\u2010ABI group (ABI\u00a0=\u00a00.9\u20101.3, n\u00a0=\u00a0272), and high\u2010ABI group (ABI\u00a0&gt;\u00a01.3, n\u00a0=\u00a0103). According to the manifestation of coronary CTA, the patients were divided into CAD group (n\u00a0=\u00a0348) and non\u2010CAD group (n\u00a0=\u00a0286). Their clinical data and biochemical parameters were compared and analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of CAD in low\u2010ABI group (90%) was significantly higher than that of normal\u2010ABI group (33%) and high\u2010ABI group (25%) (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Spearman correlation analysis showed that age, sex, duration, spontaneous bacterial peritonitis, total cholesterol (TC), triglyceride, low\u2010density lipoprotein cholesterol (LDL\u2010C), serum creatinine, and glycosylated haemoglobin (HbA<jats:sub>1c<\/jats:sub>) were positively correlated with CAD, and high\u2010density lipoprotein cholesterol (HDL\u2010C), glomerular filtration rate, and ABI were negatively correlated with CAD. Logistic regression analysis further revealed that age, sex, duration, TC, HDL\u2010C, LDL\u2010C, HbA<jats:sub>1c<\/jats:sub>, and ABI were independent risk factors of CAD. After all potential confounders is adjusted, the risk of CAD in low\u2010ABI group still increased over four times than the normal\u2010ABI group (odds ratio [OR], 5.32; 95% CI, 1.973\u201016.5; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In female patients, this risk increased more than nine times (OR, 10.63; 95% CI, 3.416\u201017.8; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Receiver\u2010operating characteristic analysis indicated that ABI\u00a0&lt;\u00a01.045 predicted the occurrence of CAD (sensitivity, 79.7%; specificity, 71.5%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ABI is an independent risk factor for CAD and may be a potential simple screening instrument for CAD in Chinese type 2 diabetic patients, especially in elder women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3076","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T21:29:00Z","timestamp":1537910940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The value of ankle\u2010branchial index screening for cardiovascular disease in type 2 diabetes"],"prefix":"10.1002","volume":"35","author":[{"given":"Lei","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Centre of Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai Key Clinical Centre of Metabolic Diseases, Shanghai Institute for Diabetes  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3059-1281","authenticated-orcid":false,"given":"Rui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Centre of Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai Key Clinical Centre of Metabolic Diseases, Shanghai Institute for Diabetes  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohan","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Centre of Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai Key Clinical Centre of Metabolic Diseases, Shanghai Institute for Diabetes  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Centre of Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai Key Clinical Centre of Metabolic Diseases, Shanghai Institute for Diabetes  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Centre of Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai Key Clinical Centre of Metabolic Diseases, Shanghai Institute for Diabetes  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Centre of Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai Key Clinical Centre of Metabolic Diseases, Shanghai Institute for Diabetes  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianxi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Medical Centre of Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai Key Clinical Centre of Metabolic Diseases, Shanghai Institute for Diabetes  Shanghai 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