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The aim of this study was to test the effect of ABA on the perfused rat pancreas and intestine, to verify the insulin\u2010 and incretin\u2010releasing actions of ABA in controlled physiological models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Rat pancreas and small intestine were perfused with solutions containing ABA at high\u2010micromolar concentrations, or control secretagogues. Insulin and GLP\u20101 concentrations in the venous effluent were analysed by radioimmunoassay, and ABA levels were determined by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High micromolar concentrations of ABA induced GLP\u20101 secretion from the proximal half of the small intestine and insulin secretion from pancreas. GLP\u20101 stimulated ABA secretion from pancreas in a biphasic manner. Notably, a positive correlation was found between the ABA area under the curve (AUC) and the insulin AUC upon GLP\u20101 administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate the existence of a cross talk between GLP\u20101 and ABA, whereby ABA stimulates GLP\u20101 secretion, and vice versa. Release of ABA could be considered as a new promising molecule in the strategy of type 2 diabetes treatment and as a new endogenous hormone in the regulation of glycaemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3102","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T12:15:12Z","timestamp":1542975312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Abscisic acid stimulates the release of insulin and of GLP\u20101 in the rat perfused pancreas and intestine"],"prefix":"10.1002","volume":"35","author":[{"given":"Valeria","family":"Booz","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, Section of Biochemistry, and CEBR University of Genova  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte Bayer","family":"Christiansen","sequence":"additional","affiliation":[{"name":"NovoNordisk Foundation Center for 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