{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:47:41Z","timestamp":1753868861823,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004825","name":"Nordea-fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Statins are widely used to lower cholesterol concentrations in both primary and secondary prevention of cardiovascular disease. The treatment increases the risk of muscle pain (myalgia) and of type 2 diabetes. However, the underlying mechanisms remain disputed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated whether statin induced myalgia is coupled to impaired glucose homeostasis using oral glucose tolerance test (OGTT), intravenous glucose tolerance test (IVGTT), and the hyperinsulinemic euglycemic clamp. We performed a cross\u2010sectional study of statin users without CVD (primary prevention) stratified into a statin myalgic (M; <jats:italic>n<\/jats:italic>\u00a0=\u00a025) and a non\u2010myalgic (NM; <jats:italic>n<\/jats:italic>\u00a0=\u00a039) group as well as a control group (C; <jats:italic>n<\/jats:italic>\u00a0=\u00a020) consisting of non\u2010statin users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A reduction in the insulin secretion rate during the OGTT was observed in the myalgic group compared with the non\u2010myalgic group (AUC ISR<jats:sub>OGTT<\/jats:sub>, C: 1032 (683 \u2010 1500); M: 922 (678 \u2010 1091); NM: 1089 (933 \u2010 1391) pmol\u00b7L<jats:sup>\u22121<\/jats:sup>\u00b7min (median with 25%\u201075% percentiles), but no other measurements indicated impaired \u03b2\u2010cell function. We found no other differences between the three groups for other measurements in the OGTT, IVGTT, and euglycemic clamp. Muscle protein content of GLUT4 and hexokinase II was similar between the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that statin users in primary prevention experiencing myalgia do not have impaired glucose homeostasis compared with other statin users or non\u2010users. We consider this an important aspect in the dialogue between physician and patient regarding statin treatment and adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3110","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T22:03:57Z","timestamp":1544047437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Glucose homeostasis in statin users\u2014The LIFESTAT study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-2591","authenticated-orcid":false,"given":"Thomas","family":"Morville","sequence":"first","affiliation":[{"name":"Xlab, Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine","family":"Dohlmann","sequence":"additional","affiliation":[{"name":"Xlab, Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja B.","family":"Kuhlman","sequence":"additional","affiliation":[{"name":"Xlab, Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tine","family":"Monberg","sequence":"additional","affiliation":[{"name":"Xlab, Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimmi","family":"Torp","sequence":"additional","affiliation":[{"name":"Xlab, Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolette","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen","family":"Larsen","sequence":"additional","affiliation":[{"name":"Xlab, Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Clinical Research Centre Medical University of Bialystok  Bialystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rn W.","family":"Helge","sequence":"additional","affiliation":[{"name":"Xlab, Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming","family":"Dela","sequence":"additional","affiliation":[{"name":"Xlab, Department of Biomedical Sciences, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Geriatrics Bispebjerg University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4992"},{"key":"e_1_2_10_4_1","unstructured":"US Food and Drug Administration F.FDA Drug Safety Communication: important safety label changes to cholesterol\u2010lowering statin drugs [Internet].2012. 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