{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:59:47Z","timestamp":1767855587696,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The risk of gestational diabetes mellitus (GDM) is increased in overweight and obese women potentially involving secreted mediators from adipose tissue. Our main aim was to evaluate if circulating adipokines and monocyte\/macrophage markers were dysregulated in GDM and the influence body mass and indices of glucose metabolism had on this association. We further explored if early detection of these markers improved prediction of GDM and if they remained modified during long\u2010term follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Population\u2010based prospective cohort study in 273 pregnant women with markers measured four times during pregnancy and at 5\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>sCD163 was higher (25% at 14\u201016\u00a0weeks, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and adiponectin lower (\u221217% at 14\u201016\u00a0weeks, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) early in pregnancy and at 5\u2010year follow\u2010up in GDM women, independent of BMI, and other GDM risk factors. Leptin, adiponectin, and chemerin were robustly associated with glucose metabolism throughout pregnancy while sCD163 was inversely associated with \u03b2\u2010cell function early in pregnancy in women with increased BMI. Finally, the markers at 14 to 16\u00a0weeks displayed modest discriminatory properties with regard to prediction of GDM (AUC\u00a0&lt;\u00a00.7). Using a combination of fasting glucose and sCD163, 53% of GDM could be identified when 25% of the population scored positive suggesting some merit in a multimarker approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>sCD163 and adiponectin were dysregulated in GDM, independent of body mass. None of the adipokines or monocyte\/macrophage activation markers displayed clinically useful properties alone for early detection of GDM. Activation of monocytes\/macrophages may be an important event in the early development of GDM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3114","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T20:06:44Z","timestamp":1544731604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Adipokines and macrophage markers during pregnancy\u2014<scp>P<\/scp>ossible role for <scp>sCD163<\/scp> in prediction and progression of gestational diabetes mellitus"],"prefix":"10.1002","volume":"35","author":[{"given":"Thor","family":"Ueland","sequence":"first","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital, Rikshospitalet  Oslo Norway"},{"name":"Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Section of Clinical Immunology and Infectious Diseases Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika E.","family":"Michelsen","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital, Rikshospitalet  Oslo Norway"},{"name":"Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital, Rikshospitalet  Oslo Norway"},{"name":"Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Section of Clinical Immunology and Infectious Diseases Oslo University Hospital, Rikshospitalet  Oslo Norway"},{"name":"K.G. Jebsen Inflammatory Research Center University of Oslo  Oslo Norway"},{"name":"K. G. Jebsen Thrombosis Research and Expertise Center University of Troms\u00f8  Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tore","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Department of Obstetrics Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Bollerslev","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oslo  Oslo Norway"},{"name":"Section of Specialized Endocrinology, Department of Endocrinology Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-4726","authenticated-orcid":false,"given":"Tove","family":"Lekva","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine Oslo University Hospital, Rikshospitalet  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1567"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2559a"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29709"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26498"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319451"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/35053000"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03198.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1731"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1964"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319246"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039324"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31614-z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0153"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136892"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0492-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164117728011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0345-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.5.1104"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-S011"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.307"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_8_26_1","unstructured":"Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. Geneva;2013."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.01.013"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12255-6"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.154724"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20376"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-14-0107"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101327"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12375"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3348"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/309548"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5845"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0818-9641.2004.01277.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1199671"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1320382"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-018-0826-1"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.08.003"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12484"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002310"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.3114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3114","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T13:07:12Z","timestamp":1694696832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.3114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,7]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/dmrr.3114"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.3114","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,7]]},"assertion":[{"value":"2018-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3114"}}