{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:56:39Z","timestamp":1783468599414,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010353","name":"Hellenic Atherosclerosis Society","doi-asserted-by":"publisher","award":["HAS2003"],"award-info":[{"award-number":["HAS2003"]}],"id":[{"id":"10.13039\/501100010353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10\u2010year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common anthropometric indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 2001 to 2002, the ATTICA study (Greece) recruited a random sample of 1514 and 1528 CVD\u2010free men (18\u201087\u00a0years old) and women (18\u201089\u00a0years old), respectively. Sociodemographic, lifestyle, clinical, and biochemical characteristics of participants were measured at baseline, and the 10\u2010year follow\u2010up was performed during 2011 to 2012. After excluding participants with diabetes at baseline and participants without complete follow\u2010up information regarding diabetes status and\/or baseline VAI values, the working sample consisted of 1049 participants. In this sample, the predictive value of baseline VAI value was studied in relation to 10\u2010year diabetes incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirty\u2010three incident cases of diabetes were documented (10\u2010year incidence: 12.7%). In the fully adjusted model, VAI significantly increased diabetes risk by 22% (OR per 1\u2010unit increase =1.22; 95%CI, 1.09\u20101.37). Markers of oxidative stress and inflammation were found to, at least partly, mediate this relationship. Also, a moderating effect of menstruation status was revealed among women. VAI showed the highest predictive ability and contributed the most, along with waist\u2010to\u2010height ratio, to the correct classification of participants who developed diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present findings suggest that VAI may be a useful index for predicting long\u2010term diabetes development and may exhibit better predictive ability to commonly used anthropometric indices.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3161","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T06:09:37Z","timestamp":1553580577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Visceral adiposity index outperforms common anthropometric indices in predicting 10\u2010year diabetes risk: Results from the ATTICA study"],"prefix":"10.1002","volume":"35","author":[{"given":"Efi","family":"Koloverou","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-153X","authenticated-orcid":false,"given":"Demosthenes B.","family":"Panagiotakos","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kyrou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University  Athens Greece"},{"name":"Aston Medical Research Institute, Aston Medical School Aston University  Birmingham UK"},{"name":"WISDEM University Hospital Coventry and Warwickshire NHS Trust  Coventry UK"},{"name":"Translational &amp; 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