{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:10:41Z","timestamp":1791951041591,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Type 1 diabetes mellitus (T1DM) is characterized by irreversible islet \u03b2 cell destruction. During the progression of this disease, some patients with T1DM experience a phase of remission known as honeymoon or partial remission (PR) that is mainly characterized by satisfactory glycemic control and the transient recovery of islet \u03b2 cell function. This special phase is a good model for studying the mechanism of \u03b2 cell protection, might serve as a proper intervention period for immunotherapy, and may be related to disease prognosis. This special stage is highly valuable for studies aiming to identify possible targets that may be used to cure T1DM. An in\u2010depth understanding of the diagnosis, epidemiology, and possible mechanisms of the PR phase is highly needed. In general, patients enter the PR phase approximately 3\u00a0months after starting insulin therapy, and this phase could be sustained for 6 to 9\u00a0months. Current research increasingly focuses on the metabolic and immunological aspects to constantly update our understanding of this phase. This review concentrates on the PR phase of T1DM to provide a comprehensive outlook of its epidemiology, diagnostic criteria, and underlying immune metabolic mechanisms.<\/jats:p>","DOI":"10.1002\/dmrr.3207","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T12:50:01Z","timestamp":1564059001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["The remission phase in type 1 diabetes: Changing epidemiology, definitions, and emerging immuno\u2010metabolic mechanisms"],"prefix":"10.1002","volume":"36","author":[{"given":"Ting","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Metabolism and Endocrinology, The Second Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, National Clinical Research Center for Metabolic Disease Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, The Second Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, National Clinical Research Center for Metabolic Disease Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, The Second Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, National Clinical Research Center for Metabolic Disease Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, The Second Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, National Clinical Research Center for Metabolic Disease Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, The Second Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, National Clinical Research Center for Metabolic Disease Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-1838","authenticated-orcid":false,"given":"Zhiguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, The Second Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Key Laboratory of Diabetes Immunology (Central South University), Ministry of Education, National Clinical Research Center for Metabolic Disease Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12376"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2016.07.005"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12097"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb14837.x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.09.002"},{"key":"e_1_2_14_7_1","first-page":"332","article-title":"Stabilization of the diabetic child","volume":"59","author":"Jackson RL","year":"1940","journal-title":"Am J Dis Child"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12374"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005920050110"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12773"},{"key":"e_1_2_14_11_1","first-page":"A1","article-title":"2016 Guidelines on the management of diabetic patients. 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