{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:41:10Z","timestamp":1779892870577,"version":"3.53.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Impaired glucose tolerance (IGT) is associated with increased cardiovascular morbidity and mortality. Enhanced thromboxane (TX)\u2010dependent platelet activation plays a pivotal role in atherothrombosis and characterizes type 2 diabetes mellitus (DM). Whether this also pertains to IGT is currently unknown.<\/jats:p><jats:p>We investigated whether TXA<jats:sub>2<\/jats:sub>\u2010dependent platelet activation, as reflected by 11\u2010dehydro\u2010TXB<jats:sub>2<\/jats:sub> (TXM) urinary excretion, is comparably abnormal in IGT as in DM, is persistent over long\u2010term follow\u2010up, changes as a function of metabolic disease progression, and is influenced by food intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively investigated subjects with IGT (n = 48) and two control groups with DM diagnosed either less than 12 months (n = 60) or 12 months or more (n = 58).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline TXM excretion was comparable between subjects with IGT and DM, with no evidence of a circadian variation. During a 36\u2010month follow\u2010up, urinary TXM excretion was stable over time in the DM groups, while tended to increase in subjects with IGT. Increasing urinary TXM excretion over time was observed in the subjects who progressed to diabetes vs nonprogressors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that TXA<jats:sub>2<\/jats:sub>\u2010dependent platelet activation was at least as high in IGT as in patients with DM and further increased over time, especially in those who progressed to overt diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3232","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T16:30:28Z","timestamp":1572539428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["In vivo thromboxane\u2010dependent platelet activation is persistently enhanced in subjects with impaired glucose tolerance"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4593-905X","authenticated-orcid":false,"given":"Francesca","family":"Santilli","sequence":"first","affiliation":[{"name":"Department of Medicine and Aging and Center of Aging Science and Translational Medicine (CESI\u2010Met) University of Chieti \u201cG. D'Annunzio\u201d School of Medicine  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2636-6487","authenticated-orcid":false,"given":"Francesco","family":"Zaccardi","sequence":"additional","affiliation":[{"name":"Diabetes Care Unit Catholic University School of Medicine and Fondazione Policlinico Universitario \u201cA. Gemelli\u201d Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)  Rome Italy"},{"name":"Leicester Diabetes Centre, Leicester General Hospital  Leicester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Liani","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging and Center of Aging Science and Translational Medicine (CESI\u2010Met) University of Chieti \u201cG. D'Annunzio\u201d School of Medicine  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Petrucci","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology Catholic University School of Medicine  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Simeone","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging and Center of Aging Science and Translational Medicine (CESI\u2010Met) University of Chieti \u201cG. D'Annunzio\u201d School of Medicine  Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6220-686X","authenticated-orcid":false,"given":"Dario","family":"Pitocco","sequence":"additional","affiliation":[{"name":"Diabetes Care Unit Catholic University School of Medicine and Fondazione Policlinico Universitario \u201cA. 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