{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:45:44Z","timestamp":1790595944058,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T00:00:00Z","timestamp":1578700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of hyperbaric oxygen therapy (HBO) in the treatment of certain types of diabetic foot ulcers (DFU) has been the topic of much debate and disagreement over the last several decades. In this review, the evidence for its use is presented and discussed by two experts in DFU management. Whereas some randomized controlled trials suggest that HBO may speed the healing of certain ischaemic or neuroischaemic ulcers after the failure of standard of care, most recent trials have been negative. No RCT is perfect, and the weaknesses of RCTs in this therapeutic area are discussed. It can be concluded that the indications for the use of HBO remain unclear, and that large, rigorously designed and executed RCTs are required to clarify the use of HBO in DFU treatment.<\/jats:p>","DOI":"10.1002\/dmrr.3233","type":"journal-article","created":{"date-parts":[[2020,1,12]],"date-time":"2020-01-12T07:09:15Z","timestamp":1578812955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Hyperbaric oxygen therapy in diabetic foot ulceration: Useless or useful? A battle"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1522-3920","authenticated-orcid":false,"given":"Magnus","family":"L\u00f6ndahl","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences in Lund Lund University  Lund Sweden"},{"name":"Department of Endocrinology Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.M.","family":"Boulton","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Endocrinology, and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine, and Health University of Manchester  Manchester UK"},{"name":"Manchester Diabetes Centre Manchester Royal Infirmary  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,11]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"183","article-title":"Hyperbaric oxygen therapy: a physiological approach to a selected problem wound healing","volume":"8","author":"Boykin J","year":"1996","journal-title":"Wounds"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.5940"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734613486154"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.10402.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00234.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1946-y"},{"key":"e_1_2_8_8_1","unstructured":"HartGB StraussM. 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Resurgence in diabetes\u2010related complications. JAMA 2019. Apr 15.doi. 10. 1001 JAMA 2019. 3471."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30262-6"},{"key":"e_1_2_8_20_1","first-page":"197","article-title":"Compromised breast flaps treated with leech therapy, hyperbaric oxygen, pentoxifylline and topical nitroglycerin: a case report","volume":"42","author":"Moffat AD","year":"2015","journal-title":"Undersea Hyperb Med"},{"key":"e_1_2_8_21_1","first-page":"60","article-title":"Anti\u2010infective therapy without antimicrobials: apparent successful treatment of multidrug resistant osteomyelitis with hyperbaric oxygen therapy","volume":"6","author":"Goerger E","year":"2016","journal-title":"ID Cases"},{"key":"e_1_2_8_22_1","first-page":"CD004123","article-title":"Hyperbaric oxygen therapy for chronic wounds","volume":"6","author":"Kranke P","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0393"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12155"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3283"},{"key":"e_1_2_8_27_1","first-page":"133","article-title":"Poorly designed research does not help clarify the role of hyperbaric oxygen in the treatment of chronic diabetic foot ulcers","volume":"46","author":"Mutluoglu M","year":"2016","journal-title":"Diving Hyperb Med"},{"key":"e_1_2_8_28_1","first-page":"1300","article-title":"Editorial: Useless tank to become useful tanks","volume":"118","year":"1942","journal-title":"JAMA"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3233","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dmrr.3233","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T23:33:43Z","timestamp":1694043223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.3233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,11]]},"references-count":27,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/dmrr.3233"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.3233","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,11]]},"assertion":[{"value":"2019-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3233"}}