{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:44:40Z","timestamp":1791499480941,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK121298"],"award-info":[{"award-number":["R01 DK121298"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R18 DK098742"],"award-info":[{"award-number":["R18 DK098742"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK104845"],"award-info":[{"award-number":["R01 DK104845"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIDDK R01\u2010DK\u2010071066"],"award-info":[{"award-number":["NIDDK R01\u2010DK\u2010071066"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012301","name":"Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine","doi-asserted-by":"publisher","award":["P30 DK020541"],"award-info":[{"award-number":["P30 DK020541"]}],"id":[{"id":"10.13039\/100012301","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Methods<\/jats:title>\n                    <jats:p>This review summarizes recent advances regarding the role of psychological factors in people with a diabetic foot ulcer (DFU). It describes the detrimental effects of diabeticfoot complications and in particular, Charcot Neuroarthropathy (CN), on health status and quality of life (QoL) and emphasizes the importance of utilizing DFU\u2010specific assessment tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Diabetic neuropathy (DN)\u2010related postural instability is key in generating depression in high DFU risk patients and in predicting offloading non\u2010adherence those with active DFUs. Patients' views of their own DFU risk are largely inconsistent with biomedical models, resulting in a lack of preventive foot self\u2010care. Furthermore, DFUs are a source of specific emotional responses, with fear of amputation predominant. While fear of amputation is associated with better preventive foot self\u2010care, it appears to be linked to DFU non\u2010healing, though mechanisms are yet to be elucidated. Until now, systemically released stress hormones were recognized as the only biological mechanism through which psychological stress influences healing. Recently, the skin has been found to be an extra\u2010adrenal site for glucocorticoid synthesis with local, tissue\u2010specific cortisol implicated in DFU non\u2010healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These observations could potentially lead to future targets for therapeutic and psychological interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3257","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T08:09:39Z","timestamp":1576656579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Psychosocial research in the diabetic foot: Are we making progress?"],"prefix":"10.1002","volume":"36","author":[{"given":"Loretta","family":"Vileikyte","sequence":"first","affiliation":[{"name":"Division of Diabetes, Endocrinology and Gastroenterology University of Manchester  Manchester UK"},{"name":"Department of Endocrinology and Dermatology University of Miami  Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8172-9818","authenticated-orcid":false,"given":"Frans","family":"Pouwer","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Southern Denmark  Odense Denmark"},{"name":"STENO Diabetes Center Odense  Odense Denmark"},{"name":"School of Psychology Deakin University  Geelong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Ferkauf Graduate School of Psychology Yeshiva University  Bronx New York"},{"name":"Albert Einstein College of Medicine  Bronx New York"},{"name":"New York Regional Center for Diabetes Translation Research  Bronx New 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