{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:20:21Z","timestamp":1793895621127,"version":"4.8.0"},"reference-count":121,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The International Working Group on the Diabetic Foot (IWGDF) has published evidence\u2010based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of the literature centred on the following: the Population (P), Intervention (I), Comparator (C) and Outcomes (O) framework; the use of the SIGN guideline\/Cochrane review system; and the 21 point scoring system advocated by IWGDF\/EWMA. This has resulted in 13 recommendations. The recommendation on sharp debridement and the selection of dressings remain unchanged from the last recommendations published in 2016. The recommendation to consider negative pressure wound therapy in post\u2010surgical wounds and the judicious use of hyperbaric oxygen therapy in certain non\u2010healing ischaemic ulcers also remains unchanged. Recommendations against the use of growth factors, autologous platelet gels, bioengineered skin products, ozone, topical carbon dioxide, nitric oxide or interventions reporting improvement of ulcer healing through an alteration of the physical environment or through other systemic medical or nutritional means also remain. New recommendations include consideration of the use of sucrose\u2010octasulfate impregnated dressings in difficult to heal neuro\u2010ischaemic ulcers and consideration of the use of autologous combined leucocyte, platelet and fibrin patch in ulcers that are difficult to heal, in both cases when used in addition to best standard of care. A further new recommendation is the consideration of topical placental derived products when used in addition to best standard of care.<\/jats:p>","DOI":"10.1002\/dmrr.3283","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T13:07:41Z","timestamp":1584364061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":174,"title":["Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update)"],"prefix":"10.1002","volume":"36","author":[{"given":"Gerry","family":"Rayman","sequence":"first","affiliation":[{"name":"Diabetes Centre and Research Unit East Suffolk and North East Essex Foundation Trust  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth","family":"Vas","sequence":"additional","affiliation":[{"name":"Diabetes Foot Clinic, King's College Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Dhatariya","sequence":"additional","affiliation":[{"name":"Department of Diabetes Norfolk and Norwich University Hospitals NHS Foundation Trust, and University of East Anglia  Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie","family":"Driver","sequence":"additional","affiliation":[{"name":"Brown University School of Medicine  Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Hartemann","sequence":"additional","affiliation":[{"name":"Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, APHP Paris 6 University, ICAN  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Londahl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Skane University Hospital, Lund, and Department of Clinical Sciences  Lund Lund University Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Piaggesi","sequence":"additional","affiliation":[{"name":"Diabetic Foot Section, Department of Medicine University of Pisa  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Apelqvist","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital of Malm\u00f6  Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Attinger","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Medstar Georgetown University, Hospital  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran","family":"Game","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology University Hospitals of Derby and Burton NHS Foundation Trust  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the International Working Group on the Diabetic Foot (IWGDF)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30012-2"},{"key":"e_1_2_9_3_1","article-title":"GRADE evidence to decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: clinical practice guidelines","volume":"353","author":"Alonso\u2010Coello P","year":"2016","journal-title":"BMJ"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3284"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3267"},{"key":"e_1_2_9_7_1","first-page":"CD009101","article-title":"Hydrogel dressings for healing diabetic foot ulcers","volume":"7","author":"Dumville JC","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_8_1","first-page":"CD009101","article-title":"Hydrogel dressings for healing diabetic foot ulcers","volume":"9","author":"Dumville JC","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2018.0784"},{"issue":"3","key":"e_1_2_9_10_1","first-page":"57","article-title":"Clinical outcomes associated with serial sharp debridement of diabetic foot ulcers with and without clostridial collagenase ointment","volume":"26","author":"Motley TA","year":"2014","journal-title":"Wounds"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.2002.10603.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2007.00490.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2.446"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.7547\/0950254"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2008.00564.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1757-7861.2010.00087.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2013.09.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta13540"},{"issue":"2","key":"e_1_2_9_19_1","first-page":"156","article-title":"Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers","volume":"8","author":"Delgado\u2010Enciso I","year":"2018","journal-title":"Biomed Rep"},{"key":"e_1_2_9_20_1","article-title":"Topical antimicrobial agents for treating foot ulcers in people with diabetes","volume":"6","author":"Dumville JC","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/218283"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"44","article-title":"A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers","volume":"63","author":"Shukrimi A","year":"2008","journal-title":"Med J Malaysia"},{"issue":"4","key":"e_1_2_9_23_1","first-page":"1082","article-title":"Comparison between honey and povidone\u2010iodine\/normal saline dressing for management of Wagner'grade s I & II diabetic foot ulcers","volume":"7","author":"Rehman E","year":"2013","journal-title":"Pak J Med Health Sci"},{"issue":"4","key":"e_1_2_9_24_1","first-page":"402","article-title":"Comparison of conventional pyodine dressing with honey dressing for the treatment of diabetic foot ulcers","volume":"26","author":"Jan WA","year":"2012","journal-title":"Journal of Postgraduate Medical Institute (Peshawar\u2010Pakistan)"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2012.01082.x"},{"issue":"10","key":"e_1_2_9_26_1","first-page":"721","article-title":"A randomized, controlled clinical trial of honey\u2010impregnated dressing for treating diabetic foot ulcer","volume":"25","author":"Imran M","year":"2015","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_9_27_1","first-page":"CD005083","article-title":"Honey as a topical treatment for wounds","volume":"3","author":"Jull AB","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2001.00466.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7340641"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3159798"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164118769528"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12428"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13304-017-0461-9"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0684-2"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12275"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30438-2"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.8.2378"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/567834"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2002.1911"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1754"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2160"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-2001"},{"issue":"1","key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2337\/dc17-0654","article-title":"Hyperbaric oxygen therapy in the treatment of ischemic lower extremity ulcers in patients with diabetes: results of the DAMO2CLES Multicenter randomized clinical trial","volume":"41","author":"Santema KTB","year":"2018","journal-title":"Diabetes Care"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1946-y"},{"issue":"6","key":"e_1_2_9_45_1","first-page":"24","article-title":"Topical wound oxygen therapy in the treatment of severe diabetic foot ulcers: a prospective controlled study","volume":"56","author":"Blackman E","year":"2010","journal-title":"Ostomy Wound Manage"},{"issue":"3","key":"e_1_2_9_46_1","first-page":"52","article-title":"Enhanced healing and cost\u2010effectiveness of low\u2010pressure oxygen therapy in healing necrotic wounds: a feasibility study of technology transfer","volume":"46","author":"Heng M","year":"2000","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2018.27.Sup9.S30"},{"issue":"4","key":"e_1_2_9_48_1","first-page":"12","article-title":"A prospective, randomized, blinded, controlled trial comparing transdermal continuous oxygen delivery to moist wound therapy for the treatment of diabetic foot ulcers","volume":"63","author":"Driver VR","year":"2017","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_9_49_1","first-page":"CD010318","article-title":"Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus","volume":"10","author":"Liu Z","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12190"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67695-7"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2196"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2173-5077(09)70086-9"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.02.050"},{"issue":"2","key":"e_1_2_9_55_1","first-page":"33","article-title":"Use of vacuum assisted closure therapy in the treatment of diabetic foot wounds","volume":"2","author":"Dalla Paola L","year":"2010","journal-title":"J Diabetic Foot Complications"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-003-0065-3"},{"issue":"8","key":"e_1_2_9_57_1","first-page":"28","article-title":"Vacuum\u2010assisted closure versus saline\u2010moistened gauze in the healing of postoperative diabetic foot wounds","volume":"46","author":"McCallon SK","year":"2000","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.7547\/0970351"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-8-4"},{"issue":"11","key":"e_1_2_9_60_1","first-page":"789","article-title":"Comparison of negative pressure wound therapy using vacuum\u2010assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers","volume":"25","author":"Sajid MT","year":"2015","journal-title":"J Coll Physicians Surg Pak"},{"issue":"7","key":"e_1_2_9_61_1","first-page":"180","article-title":"Comparing calcium alginate dressings to vacuum\u2010assisted closure: a clinical trial","volume":"27","author":"Vassallo IM","year":"2015","journal-title":"Wounds"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v5.23345"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v015a07"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12635"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12097"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12329"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12395"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001095"},{"issue":"7","key":"e_1_2_9_69_1","first-page":"248","article-title":"Comparison of a bioimplant dressing with a wet dressing for the treatment of diabetic foot ulcers: a randomized","volume":"28","author":"Mohajeri\u2010Tehrani MR","year":"2016","journal-title":"Controlled Clinical Trial Wounds"},{"issue":"3","key":"e_1_2_9_70_1","first-page":"70","article-title":"A prospective, randomized, multicenter, controlled evaluation of the use of dehydrated amniotic membrane allograft compared to standard of care for the closure of chronic diabetic foot ulcer","volume":"28","author":"Snyder RJ","year":"2016","journal-title":"Wounds: A Compendium of Clinical Research and Practice"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12645"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12976"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13001"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12566"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12332"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(91)90247-R"},{"issue":"6","key":"e_1_2_9_77_1","first-page":"68","article-title":"A prospective, randomized, controlled trial of autologous platelet\u2010rich plasma gel for the treatment of diabetic foot ulcers","volume":"52","author":"Driver VR","year":"2006","journal-title":"Ostomy Wound Manage"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181cb6589"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12294"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2016.04.023"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70245-8"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.5.822"},{"issue":"5","key":"e_1_2_9_83_1","first-page":"273","article-title":"Clinical study of various growth factors on the improvement of impaired healing ulcers in patients with diabetic disease","volume":"13","author":"Feng J","year":"1999","journal-title":"Zhongguo xiu fu chong jian wai ke za zhi= Zhongguo xiufu chongjian waike zazhi= Chinese journal of reparative and reconstructive surgery"},{"issue":"1","key":"e_1_2_9_84_1","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.4081\/cp.2013.e9","article-title":"Comparative study of different treatment options of grade III and IV diabetic foot ulcers to reduce the incidence of amputations","volume":"3","author":"Khandelwal S","year":"2013","journal-title":"Clin Pract"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.7547\/1000155"},{"issue":"4","key":"e_1_2_9_86_1","first-page":"83","article-title":"Topical platelet\u2010derived growth factor vs placebo therapy of diabetic foot ulcers offloaded with windowed casts: a randomized, controlled trial","volume":"27","author":"Ma C","year":"2015","journal-title":"Wounds"},{"issue":"9","key":"e_1_2_9_87_1","first-page":"3887","article-title":"Platelet derived growth factor in diabetic lower extremity ulcer: a randomized, double blind, placebo controlled study in Indian condition","volume":"7","author":"Samuel A","year":"2016","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30240-7"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12357"},{"key":"e_1_2_9_90_1","first-page":"e10","article-title":"Healing rates in a Multicenter assessment of a sterile, room temperature, acellular dermal matrix versus conventional care wound management and an active comparator in the treatment of full\u2010thickness diabetic foot ulcers","volume":"16","author":"Walters J","year":"2016","journal-title":"Eplasty"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.02.023"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050389"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2707"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2246"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12187"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-9668.136160"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12005"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2016.25.11.641"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.09.024"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-2109-2"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-865020150120000010"},{"key":"e_1_2_9_102_1","first-page":"107","article-title":"Effects of low level laser therapy and high voltage stimulation on diabetic wound healing. Revista de la Universidad Industrial de Santander","volume":"46","author":"Sandoval Ort\u00edz MC","year":"2014","journal-title":"Salud"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0774"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2016.02.001"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2014.04.007"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.32444"},{"issue":"11","key":"e_1_2_9_107_1","first-page":"293","article-title":"Effect of high\u2010pressure, intermittent pneumatic compression for the treatment of peripheral arterial disease and critical limb ischemia in patients without a surgical option","volume":"27","author":"Alvarez OM","year":"2015","journal-title":"Wounds"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2016.25.12.704"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734614568374"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734617740254"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12537"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-017-1056-5"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2017.06.010"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2016.06.017"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2970"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2004.13.6.26627"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02527.x"},{"key":"e_1_2_9_118_1","first-page":"7","article-title":"Effects of iloprost (a prostacyclin analogue) on the endothelial dysfunction and foot ulcers in diabetic patients with peripheral arterial disease","volume":"16","author":"Sert M","year":"2008","journal-title":"International Journal of Diabetes and Metabolism"},{"issue":"1","key":"e_1_2_9_119_1","first-page":"84","article-title":"Pentoxifylline: a new armamentarium in diabetic foot ulcers","volume":"8","author":"Rewale V","year":"2014","journal-title":"J Clin Diagn Res"},{"issue":"1","key":"e_1_2_9_120_1","first-page":"35","article-title":"Effects of intravenous Semelil (ANGIPARSTM) on diabetic foot ulcers healing: a multicenter clinical trial","volume":"16","author":"Larijani B","year":"2008","journal-title":"DARU Journal of Pharmaceutical Sciences"},{"issue":"1","key":"e_1_2_9_121_1","first-page":"41","article-title":"Clinical application of oral form of ANGIPARSTM and in combination with topical form as a new treatment for diabetic foot ulcers: a randomized clinical trial","volume":"16","author":"Bahrami A","year":"2008","journal-title":"DARU Journal of Pharmaceutical Sciences"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/892706"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.3283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dmrr.3283","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T23:33:36Z","timestamp":1694043216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.3283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":121,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/dmrr.3283"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.3283","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"2019-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3283"}}