{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:41:56Z","timestamp":1785210116806,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to investigate the efficacy of exenatide and insulin glargine in patients with newly diagnosed type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a 24\u2010week randomized controlled multicentre clinical trial. Seventy\u2010six patients were randomly assigned 1:1 to receive exenatide or insulin glargine treatment. The endpoints included changes in liver fat content (LFC), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) measured by magnetic resonance spectroscopy, blood glucose, liver enzymes, lipid profile, body weight, and Fibrosis\u20104 index (FIB\u20104).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LFC, VAT, SAT, and FIB\u20104 were significantly reduced after exenatide treatment (\u0394LFC, \u221217.55\u2009\u00b1\u200912.93%; \u0394VAT, \u221243.57\u2009\u00b1\u200968.20\u2009cm<jats:sup>2<\/jats:sup>; \u0394SAT, \u221228.44\u2009\u00b1 51.48\u2009cm<jats:sup>2<\/jats:sup>; \u0394FIB\u20104, \u22120.10\u2009\u00b1\u20090.26; all <jats:italic>P<\/jats:italic> &lt;\u2009.05). In comparison, only LFC (\u0394LFC, \u221210.49\u2009\u00b1\u200911.38%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), and not VAT, SAT, or FIB\u20104 index (all <jats:italic>P<\/jats:italic> &gt;\u2009.05), was reduced after insulin glargine treatment. Moreover, exenatide treatment resulted in greater reductions in alanine transaminase (ALT), aspartate transaminase (AST), and gamma glutamyl transpeptidase (GGT) than insulin glargine (<jats:italic>P<\/jats:italic> &lt;\u20090.05). The body weight, waist circumference, postprandial plasma glucose, and low\u2010density lipoprotein cholesterol (LDL\u2010C) in the exenatide group also presented greater reductions than the insulin glargine group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The proportion of adverse events were comparable between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both exenatide and insulin glargine reduced LFC in patients with drug\u2010naive T2DM and NAFLD; however, exenatide showed greater reductions in body weight, visceral fat area, liver enzymes, FIB\u20104, postprandial plasma glucose, and LDL\u2010C.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3292","type":"journal-article","created":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T07:59:25Z","timestamp":1579420765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Efficacy of exenatide and insulin glargine on nonalcoholic fatty liver disease in patients with type 2 diabetes"],"prefix":"10.1002","volume":"36","author":[{"given":"Lin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital, Fudan 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