{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:10:23Z","timestamp":1792678223063,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To address the effect of a diet enriched in extra virgin olive oil (EVOO) on maternal metabolic parameters and placental proinflammatory markers in Gestational diabetes mellitus (GDM) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant women at 24\u201028\u2009weeks of gestation were enrolled: 33 GDM patients which were randomly assigned or not to the EVOO\u2010enriched group and 17 healthy controls. Metabolic parameters were determined. Peroxisome proliferator activated receptor (PPAR) \u03b3 and PPAR\u03b1 protein expression, expression of microRNA (miR)\u2010130a and miR\u2010518d (which respectively target these PPAR isoforms) and levels of proinflammatory markers were evaluated in term placentas. Matrix metalloproteinases (MMPs) activity was evaluated in term placentas and umbilical cord blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GDM patients that received the EVOO\u2010enriched diet showed reduced pregnancy weight gain (GDM\u2010EVOO:10.3\u2009\u00b1\u20090.9, GDM:14.2\u2009\u00b1\u20091.4, <jats:italic>P\u2009=<\/jats:italic> .03) and reduced triglyceridemia (GDM\u2010EVOO:231\u2009\u00b1\u200914, GDM:292\u2009\u00b1\u200921, <jats:italic>P\u2009=<\/jats:italic> .02) compared to the non\u2010EVOO\u2010enriched GDM group. In GDM placentas, the EVOO\u2010enriched diet did not regulate PPAR\u03b3 protein expression or miR\u2010130a expression, but prevented the reduced PPAR\u03b1 protein expression (<jats:italic>P<\/jats:italic> = .02 vs GDM) and the increased miR\u2010518d expression (<jats:italic>P<\/jats:italic> = .009 vs GDM). Increased proinflammatory markers (interleukin\u20101\u03b2, tumour necrosis factor\u2010\u03b1 and nitric oxide overproduction) in GDM placentas were prevented by the EVOO\u2010enriched diet (respectively <jats:italic>P<\/jats:italic> = .001, <jats:italic>P<\/jats:italic> = .001 and <jats:italic>P<\/jats:italic> = .01 vs GDM). MMPs overactivity was prevented in placenta and umbilical cord blood in the EVOO\u2010enriched GDM group (MMP\u20109: respectively <jats:italic>P<\/jats:italic> = .01 and <jats:italic>P<\/jats:italic> = .001 vs GDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A diet enriched in EVOO in GDM patients reduced maternal triglyceridemia and weight gain and has antiinflammatory properties in placenta and umbilical cord blood, possibly mediated by the regulation of PPAR pathways.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3349","type":"journal-article","created":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T10:33:15Z","timestamp":1590316395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["An extra virgin olive oil\u2010enriched diet improves maternal, placental, and cord blood parameters in <scp>GDM<\/scp> 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Lorena","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Hospital General de Agudos Dr. Ignacio Pirovano  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana","family":"Fornes","sequence":"additional","affiliation":[{"name":"Universidad de Buenos Aires (UBA) Facultad de Medicina  Buenos Aires Argentina"},{"name":"CONICET\u2014UBA, Laboratory of Reproduction and Metabolism Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Beatriz","family":"Macchi","sequence":"additional","affiliation":[{"name":"Hospital General de Agudos Dr. Ignacio Pirovano  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Gresta","sequence":"additional","affiliation":[{"name":"Hospital General de Agudos Dr. Ignacio Pirovano  Buenos Aires 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