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RCTs that comparatively evaluated the effects of DPP\u20104i treatment and placebo on patients with T2DM and reported skin\u2010related AEs were included in the analysis. The odds ratio (OR) and 95% confidence interval (CI) were calculated using the Peto's methods. The GRADE approach was used to rate the quality of evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 46 randomized placebo\u2010controlled trials, including 3 trials with reports of BP (n = 38\u2009011), that reported skin\u2010related AEs were included (n = 59\u2009332). Compared to the placebo group, the risk of developing BP was significantly higher in the DPP\u20104i treatment group (OR = 7.38, 95% CI 2.00\u201027.25, I<jats:sup>2<\/jats:sup> =\u20090%, <jats:italic>P<\/jats:italic> = .003; quality rating: very low). Additionally, DPP\u20104i treatment was associated with an increased overall risk of developing skin\u2010related AEs (OR = 1.22, 95% CI 1.02\u20101.46, I<jats:sup>2<\/jats:sup> =\u200932%, <jats:italic>P<\/jats:italic> = .03; quality rating: moderate).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis suggested that treatment with DPP\u20104is, including sitagliptin, saxagliptin, and linagliptin, was associated with an increased risk of developing BP. Additionally, the risk of developing skin\u2010related AEs increased when all DPP\u20104is were combined. Skin lesion, especially BP, should be monitored in patients with diabetes undergoing DPP\u20104i treatment. Future studies should evaluate the susceptible population and develop strategies for early detection of skin\u2010related AEs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3391","type":"journal-article","created":{"date-parts":[[2020,8,2]],"date-time":"2020-08-02T15:34:08Z","timestamp":1596382448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Dipeptidyl peptidase\u20104 inhibitor treatment and the risk of bullous pemphigoid and skin\u2010related adverse events: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"37","author":[{"given":"Wenjia","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-2168","authenticated-orcid":false,"given":"Linong","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.08.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(97)02716-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.2041"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2006.07.023"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0192-0561(97)00004-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12695"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0804"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04062.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.1073"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2014.1166"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443330"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12397"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15111"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12083"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14601"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0210"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.2352"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.05.030"},{"issue":"18","key":"e_1_2_8_20_1","first-page":"32660","article-title":"Dipeptidyl\u2010peptidase IV inhibitor\u2010associated bullous pemphigoid: a systematic review and meta\u2010analysis","volume":"0190","author":"Kridin K","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01214.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.04.015"},{"key":"e_1_2_8_24_1","unstructured":"GuyattGH BusseJW. 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