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We present a c.3544C&gt;T p.(Arg1182Trp) ABCC8 variant in a 35\u2010year\u2010old women who had pronounced microvascular diabetic complications and a charcot arthropathy necessitating a lower limb amputation. The unusual severity of the disease course prompted us to perform a systematic review of all genetic variants in MODY12. The present mutation has mostly been associated with neonatal diabetes and in only three papers reporting a MODY12. The 55 MODY12 variants show a large clinical heterogeneity, even in relatives with the same mutation, ranging from mild impaired glucose tolerance to severe insulin\u2010dependent diabetes mellitus. HbA1c at diagnosis ranged from 5% to 14% and age at diagnosis ranged from 2 to 53 years. However, several case reports lack documentation of diabetic complications. Hence, more detailed reports remain necessary to improve insight in MODY12 pathophysiology and outcome. In this article current data regarding therapeutic management are provided, and key points to consider for the individual patient affected by MODY12 are presented.<\/jats:p>","DOI":"10.1002\/dmrr.3459","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T08:28:48Z","timestamp":1619252928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["ABCC8 variants in MODY12: Review of the literature and report of a case with severe complications"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9117-7279","authenticated-orcid":false,"given":"Marijke","family":"Timmers","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology, and Metabolism Antwerp University Hospital  Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline","family":"Dirinck","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology, and Metabolism Antwerp University Hospital  Edegem Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lauwers","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Antwerp University Hospital  Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Wuyts","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Antwerp University Hospital  Edegem Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"De Block","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology, and Metabolism Antwerp University Hospital  Edegem Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.12701\/yujm.2019.00409"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-019-01543-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-016-0192-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14145"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2009.01.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23995"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12778"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12826"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2018.2018.0077"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12931"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0043"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2007.00772.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4296"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1785"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0029"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-009-0222-y"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2011.54.4.179"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0698"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0837"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2014-0429"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12447"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2019.05.002"},{"key":"e_1_2_11_24_1","unstructured":"Gurtunca Nursen VPA.Diagnose it. 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