{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:07:20Z","timestamp":1781042840847,"version":"3.54.1"},"reference-count":141,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81820108007"],"award-info":[{"award-number":["81820108007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Latent autoimmune diabetes in adults (LADA) is an autoimmune disease that shares some genetic, immunological and clinical features with both type 1 diabetes and type 2 diabetes. Immune cells including CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, B cells, macrophages and dendritic cells (DCs) have been detected in the pancreas of patients with LADA and a rat model of LADA. Therefore, similar to type 1 diabetes, the pathogenesis of LADA may be caused by interactions between islet \u03b2\u2010cells and innate and adaptive immune cells. However, the role of the immunity in the initiation and progression of LADA remains largely unknown. In this review, we have summarized the potential roles of innate immunity and immune\u2010modulators in LADA development. Furthermore, we have examined the evidence and discussed potential innate immunological reasons for the slower development of LADA compared with type 1 diabetes. More in\u2010depth mechanistic studies are needed to fully elucidate the roles of innate immune\u2010associated genes, molecules and cells in their contributions to LADA pathogenesis. Undertaking these studies will greatly enhance the development of new strategies and optimization of current strategies for the diagnosis and treatment of the disease.\n                  <\/jats:p>","DOI":"10.1002\/dmrr.3480","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T15:12:04Z","timestamp":1622905924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Innate immunity in latent autoimmune diabetes in adults"],"prefix":"10.1002","volume":"38","author":[{"given":"Juan","family":"Huang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University) Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University  Changsha Hunan China"},{"name":"Department of Internal Medicine Section of Endocrinology School of Medicine Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-2269","authenticated-orcid":false,"given":"James Alexander","family":"Pearson","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity School of Medicine Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Susan","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity School of Medicine Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Section of Endocrinology School of Medicine Yale University  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-1838","authenticated-orcid":false,"given":"Zhiguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology (Central South University) Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916939908995974"},{"issue":"2","key":"e_1_2_12_3_1","first-page":"B59","article-title":"Crucial points at diagnosis. Type 2 diabetes or slow type 1 diabetes","volume":"22","author":"Zimmet P","year":"1999","journal-title":"Diabetes Care"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1032"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2018.33.2.147"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.99"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00282516"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.2.359"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0931"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12644"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0207"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131837"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.6.995"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.12.3193"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1696"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi20-0017"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa205"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0342"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2779"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1770"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4605-3"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1691-9"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0874"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2787"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1615"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3042"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0580"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/db19-0865"},{"issue":"61","key":"e_1_2_12_29_1","first-page":"513","article-title":"Innate immunity in type 1 diabetes","volume":"11","author":"Diana J","year":"2011","journal-title":"Discov Med"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/414792a"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.08.005"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.1.188"},{"issue":"7","key":"e_1_2_12_33_1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2337\/diabetes.49.7.1106","article-title":"Aberrant macrophage cytokine production is a conserved feature among autoimmune\u2010prone mouse strains: elevated interleukin (IL)\u201012 and an imbalance in tumor necrosis factor\u2010alpha and IL\u201010 define a unique cytokine profile in macrophages from young nonobese diabetic mice","volume":"49","author":"Alleva DG","year":"2000","journal-title":"Diabetes"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0569-9"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1834"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.05.008"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.6.3749"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1572"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5041"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.2.937"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000001144"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1765"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.01.01"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62219-9"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0513-z"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3771"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0986"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050339"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05473-11"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.8.7769"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb03004.x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb03001.x"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(03)00158-7"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1581"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2005.10.001"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.291"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.092501.134942"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2299-x"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1447.058"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(98)00056-1"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-004-6239-0"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.04.002"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190418"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1733"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.38.12.1623"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.5.667"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.9.1301"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1713543114"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.12.003"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.03.010"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2185"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.03.06.db05-1417"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.5.3166"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0496"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13289"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1288.032"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04114.x"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2014.990629"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2015.016"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.10.001"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1650"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0964"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1303230"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0113013"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1880"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111615"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mjt.0000178767.67857.63"},{"issue":"5","key":"e_1_2_12_88_1","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.4049\/jimmunol.161.5.2629","article-title":"Impaired yield, phenotype, and function of monocyte\u2010derived dendritic cells in humans at risk for insulin\u2010dependent diabetes","volume":"161","author":"Takahashi K","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700442104"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03860.x"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0493"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00505-8"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201404144"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1331226"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1345"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0355"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122146"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3064"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8616373"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.581902"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.015"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-018-1660-7"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.03.006"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.06.010"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8541"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.25.17406"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.12.038"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00734.x"},{"key":"e_1_2_12_109_1","doi-asserted-by":"crossref","unstructured":"DouglasR McDonaldOL. Innate immunity. In:Clinical Immunology. Fifth Edition;2019:39\u201053.","DOI":"10.1016\/B978-0-7020-6896-6.00003-X"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.10.002"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.05.007"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1513509112"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0332-7"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.011"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.218"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.05.013"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07336"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.92"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0620-2"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12321"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0526"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.01.001"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814558116"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.21"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.suppl_2.S97"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0293"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4734063"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2088-6"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0039"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016303"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380706"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03546.x"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900305"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2008.0027"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00984.x"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2010.04.001"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3633"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3298"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.977"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2717"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1523"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.02.003"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dmrr.3480","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:26:38Z","timestamp":1692966398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.3480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":141,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/dmrr.3480"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.3480","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/DMRR.3480\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v4\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3480\/v3\/response1","asserted-by":"object"}]},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]},"assertion":[{"value":"2020-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3480"}}