{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:41:53Z","timestamp":1787838113444,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To prospectively examine the association between arthritis and type 2 diabetes (T2D) in the Chinese population and confirm this association through a comprehensive meta\u2010analysis of cohort studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Meterials and Methods<\/jats:title><jats:p>Data were from the China Health and Retirement Longitudinal Study which was started in 2011\u20132013 and followed up in 2013\u20132014 and 2015\u20132016. Arthritis was defined as self\u2010reported physician diagnosis at baseline, and incident T2D was determined by self\u2010reported physician diagnosis, fasting blood glucose \u22657.0\u00a0mmol\/L or glycosylated haemoglobin \u22656.5% during the follow\u2010ups. Cox proportional hazards regression models were used to assess the association between arthritis and risk for T2D. A meta\u2010analysis was conducted to pool our effect estimate and those from other cohort studies using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven thousand four hundred and eight participants (47.9% men; mean age: 59.3\u00a0years) were included in final analyses. During a 4\u2010year follow\u2010up, 981 participants reported incident T2D. Compared with individuals without arthritis, those with arthritis at baseline had an 18% higher risk for incident T2D (multivariable\u2010adjusted hazard ratio: 1.18; 95% confidence interval: 1.04, 1.34). In the meta\u2010analysis of 13 cohort studies including ours, a total of 2,473,514 participants were included with 121,851 incident diabetes. The pooling HR was 1.32 (95% CI: 1.21, 1.44) for the association between arthritis and diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Arthritis was associated with an increased risk of incident diabetes in Chinese adults, and the positive association was confirmed in the meta\u2010analysis of cohort studies. Our work can inform clinical trials to assess the effectiveness of arthritis treatments in reducing risk of diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3487","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T18:15:10Z","timestamp":1626891310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Arthritis is associated with an increased risk of incident diabetes in Chinese adults: A nationwide cohort study and updated meta\u2010analysis"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-5009","authenticated-orcid":false,"given":"Xue","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6965-9696","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation) School of Public Health, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-8665","authenticated-orcid":false,"given":"Xingzhong","family":"Jin","sequence":"additional","affiliation":[{"name":"Centre for Big Data Research in Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xiu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H. Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danxia","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation) School of Public Health, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Ministry of Education \u2010 Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8548-2381","authenticated-orcid":false,"given":"Chun\u2010Xia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9350-9230","authenticated-orcid":false,"given":"Xiong\u2010Fei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation) School of Public Health, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"},{"name":"The George Institute for Global Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Division of Epidemiology, Department of Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"International Diabetes Federation. IDF Diabetes Atlas Seventh Edition 2017;2017. Accessed April 26 2019.https:\/\/www.idf.org\/aboutdiabetes\/what\u2010is\u2010diabetes\/facts\u2010figures.html?tdsourcetag=s_pcqq_aiomsg"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m997"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-015-0275-y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kww125"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.02.329"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken305"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.125476"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket343"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205827"},{"key":"e_1_2_11_11_1","article-title":"Risk of type 2 diabetes among osteoarthritis patients in a prospective longitudinal study","volume":"2014","author":"Rahman MM","year":"2014","journal-title":"Internet J Rheumatol"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4703-2"},{"issue":"4","key":"e_1_2_11_13_1","first-page":"1405","article-title":"The risk of diabetes mellitus in patients with juvenile idiopathic arthritis","volume":"47","author":"Lee H","year":"2019","journal-title":"J Rheumatol"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23611"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38918"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25766"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.121259"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2016.06.041"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys203"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-015-0780-x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00045-0"},{"issue":"2","key":"e_1_2_11_22_1","first-page":"579","article-title":"2010 Chinese guidelines for the management of hypertension","volume":"39","author":"Liu LS","year":"2011","journal-title":"Chin J Hyperten"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm402"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007462"},{"key":"e_1_2_11_25_1","unstructured":"WellsGA SheaB O\u2019ConnellD et al. The Newcastle\u2013Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta\u2010analyses. Accessed July 24 2021.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key286"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22053"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399812666151123104352"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9691345"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2925"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2016.1168293"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002901"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2014.08.019"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker373"},{"issue":"2","key":"e_1_2_11_35_1","first-page":"340","article-title":"Validation of a surveillance case definition for arthritis","volume":"32","author":"Sacks JJ","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2004.12.004"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009836"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3254"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dmrr.3487","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T15:57:26Z","timestamp":1692979046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.3487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/dmrr.3487"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.3487","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"2021-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3487"}}