{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T16:36:58Z","timestamp":1790095018459,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We investigated quantitative expression, mutual aggregation and relation with hyperglycemia of insulin resistance (IR) and beta\u2010cell dysfunction (BCD) in newly diagnosed type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed IR with euglycemic hyperinsulinemic clamp and BCD with modelled glucose\/C\u2010peptide response to oral glucose in 729 mostly drug\u2010na\u00efve patients. We measured glycated hemoglobin, pre\u2010prandial, post\u2010prandial and meal\u2010related excursion of blood glucose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IR was found in 87.8% [95% confidence intervals 85.4\u201390.2] and BCD in 90.0% [87.8\u201392.2] of subjects, ranging from mild to moderate or severe. Approximately 20% of subjects had solely one defect: BCD 10.8% [8.6\u201313.1] or IR 8.6% [6.6\u201310.7]. Insulin resistance and BCD aggregated in most subjects (79.1% [76.2\u201382.1]). We arbitrarily set nine possible combinations of mild, moderate or severe IR and mild, moderate or severe BCD, finding that each had a similar frequency (\u223c10%). In multiple regression analyses parameters of glucose control were related more strongly with BCD than with IR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In newly\u2010diagnosed type 2 diabetes, IR and BCD are very common with a wide range of expression but no specific pattern of aggregation. Beta\u2010cell dysfunction is likely to play a greater quantitative role than IR in causing\/sustaining hyperglycemia in newly\u2010diagnosed type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3558","type":"journal-article","created":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T09:18:52Z","timestamp":1655630332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Insulin resistance and beta\u2010cell dysfunction in newly diagnosed type 2 diabetes: Expression, aggregation and predominance.\n                    <i>Verona Newly Diagnosed Type 2 Diabetes Study 10<\/i>"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1074-5164","authenticated-orcid":false,"given":"Enzo","family":"Bonora","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Trombetta","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Dauriz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Brangani","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona 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Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Da Prato","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Linda","family":"Boselli","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Santi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Moschetta","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Zardini","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine University and Hospital Trust of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo C.","family":"Bonadonna","sequence":"additional","affiliation":[{"name":"Department of 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