{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T01:00:37Z","timestamp":1786410037051,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To compare the association of high serum uric acid (HUA) or metabolic syndrome (MetS) with fatty liver disease (FLD) in youths with overweight\/obesity (OW\/OB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Cross\u2010sectional study of anthropometrics, biochemical variables, and liver ultrasound of 3104 individuals with OW\/OB (age 5\u201317\u00a0years). Metabolic syndrome was defined by\u00a0\u2265\u00a03 criteria among (1) high waist circumference; (2) high triglycerides; (3) low high\u2010density lipoproteins; (4) fasting glucose \u2265100\u00a0mg\/dl; (5) blood pressure \u226595\n                      <jats:sup>th<\/jats:sup>\n                      percentile in children, and \u2265130\/80\u00a0mmHg in adolescents. High serum uric acid was defined as serum UA value\u00a0\u2265\u00a075\n                      <jats:sup>th<\/jats:sup>\n                      percentile adjusted for sex. Fatty liver disease was determined by echography.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sample was stratified in four categories: (1) no HUA, no MetS (reference category); (2) MetS; (3) HUA; (4) HUA and MetS (HUA\u00a0+\u00a0MetS). The prevalence of FLD increased across the four categories from 29.9%, 44.0%, 52.2%, to 67.1%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). The ORs for the categorical variables were 1.33 (1.06\u20131.68) for MetS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), 3.19 (2.51\u20134.05) for HUA (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) and 3.72 (2.65\u20135.21) for HUA\u00a0+\u00a0MetS (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001), versus the reference category regardless of the body mass index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HUA represents a useful marker of FLD in youths with OW\/OB, given its greater ability to identify those at increased risk of the disease compared to MetS. The ability of both to predict incident FLD must be investigated in longitudinal study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3559","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T17:08:40Z","timestamp":1655831320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Uric acid versus metabolic syndrome as markers of fatty liver disease in young people with overweight\/obesity"],"prefix":"10.1002","volume":"38","author":[{"given":"Procolo","family":"Di Bonito","sequence":"first","affiliation":[{"name":"Department of Internal Medicine \"S. Maria delle Grazie\" Hospital  Pozzuoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5063-4333","authenticated-orcid":false,"given":"Giuliana","family":"Valerio","sequence":"additional","affiliation":[{"name":"Department of Movement Sciences and Wellbeing University \"Parthenope\"  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Licenziati","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Obesity and Endocrine Disease Unit Santobono\u2010Pausilipon Children's Hospital  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Sessa","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialized Surgery University of Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Miraglia del Giudice","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialized Surgery University of Campania \"Luigi Vanvitelli\"  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Morandi","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes and Metabolic Disorders Unit University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Maffeis","sequence":"additional","affiliation":[{"name":"Pediatric Diabetes and Metabolic Disorders Unit University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Giorgio","family":"Baroni","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Life, Health &amp; Environmental Sciences University of L'Aquila  Italy"},{"name":"Neuroendocrinology and Metabolic Diseases IRCCS Neuromed  Pozzilli 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