{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:44:09Z","timestamp":1778049849935,"version":"3.51.4"},"reference-count":133,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Several reports indicate that diabetes determines an increased mortality risk in patients with coronavirus disease 19 (COVID\u201019) and a good glycaemic control appears to be associated with more favourable outcomes. Evidence also supports that COVID\u201019 pneumonia only accounts for a part of COVID\u201019 related deaths. This disease is indeed characterised by abnormal inflammatory response and vascular dysfunction, leading to the involvement and failure of different systems, including severe acute respiratory distress syndrome, coagulopathy, myocardial damage and renal failure. Inflammation and vascular dysfunction are also well\u2010known features of hyperglycemia and diabetes, making up the ground for a detrimental synergistic combination that could explain the increased mortality observed in hyperglycaemic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>In this work, we conduct a narrative review on this intriguing connection. Together with this, we also present the clinical characteristics, outcomes, laboratory and histopathological findings related to this topic of a cohort of nearly 1000 subjects with COVID\u201019 admitted to a third\u2010level Hospital in Milan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found an increased mortality in subjects with COVID\u201019 and diabetes, together with an altered inflammatory profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This may support the hypothesis that diabetes and COVID\u201019 meet at the crossroads of inflammation and vascular dysfunction. (ClinicalTrials.gov NCT04463849 and NCT04382794).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3565","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T15:33:37Z","timestamp":1657726417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inflammation and vascular dysfunction: The negative synergistic combination of diabetes and COVID\u201019"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-4081","authenticated-orcid":false,"given":"Andrea Mario","family":"Bolla","sequence":"first","affiliation":[{"name":"Division of Endocrinology ASST Fatebenefratelli\u2010Sacco  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Loretelli","sequence":"additional","affiliation":[{"name":"International Center for T1D Pediatric Clinical Research Center Romeo ed Enrica Invernizzi Department of Biomedical and Clinical Science L. Sacco University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Montefusco","sequence":"additional","affiliation":[{"name":"Division of Endocrinology ASST Fatebenefratelli\u2010Sacco  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Finzi","sequence":"additional","affiliation":[{"name":"Department of Pathology ASST dei Sette Laghi  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Abdi","sequence":"additional","affiliation":[{"name":"Nephrology Division Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moufida","family":"Ben Nasr","sequence":"additional","affiliation":[{"name":"International Center for T1D Pediatric Clinical Research Center Romeo ed Enrica Invernizzi Department of Biomedical and Clinical Science L. 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