{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:20:59Z","timestamp":1791278459328,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,2,3]],"date-time":"2003-02-03T00:00:00Z","timestamp":1044230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glucagon\u2010like peptide\u20101 (GLP\u20101) is an incretin hormone that, when given exogenously, is capable of normalizing blood glucose in individuals with type 2 diabetes. Until recently most of the research on this compound had been related to its insulinotropic properties. However, GLP\u20101 also regulates insulin synthesis and proinsulin gene expression, as well as the components of the glucose\u2010sensing machinery. In addition to regulating insulin release, it is involved in regulating the secretion of at least two other islet hormones\u2014glucagon and somatostatin. Extraislet effects of GLP\u20101 include a role in the central nervous system stress response, hypothalamic\u2010pituitary function, and the suppression of gastric emptying.<\/jats:p><jats:p>Recent studies from our own and other laboratories show that GLP\u20101 can regulate islet growth and is a differentiation factor of the endocrine pancreas. This leads us to propose that GLP\u20101 and GLP\u20101 receptor agonists, in the context of long\u2010term treatment of type 2 diabetes, will have broader biological action on the endocrine pancreas than was earlier anticipated. We propose that GLP\u20101 is a growth factor for pancreatic endocrine cells and can increase islet cell mass. Here we review those reports that have highlighted its role as a factor for islet cell growth and differentiation. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/dmrr.357","type":"journal-article","created":{"date-parts":[[2003,4,3]],"date-time":"2003-04-03T17:59:18Z","timestamp":1049392758000},"page":"115-123","source":"Crossref","is-referenced-by-count":165,"title":["GLP\u20101 receptor agonists are growth and differentiation factors for pancreatic islet beta cells"],"prefix":"10.1002","volume":"19","author":[{"given":"Josephine M.","family":"Egan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Bulotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiang","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Perfetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10761"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80546-2"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2337\/diab.44.11.1249","article-title":"U.K. prospective diabetes study 16. 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