{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:25:42Z","timestamp":1773930342125,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Data regarding diabetic foot ulcers in patients after solid organ transplantation, particularly kidney transplantation, are limited. Chronic immunosuppression may be associated with impaired wound healing and a higher risk of amputations. In this study, we characterised the clinical presentation and outcomes of patients after kidney transplantation admitted to the diabetic foot unit, compared to non\u2010kidney\u2010transplant patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Data on the baseline characteristics, clinical presentation, and outcomes of all patients admitted to the diabetic foot unit of a large tertiary centre between the years 2014 and 2019 were collected. The most recent admission of each patient was considered. Primary outcomes were major amputations and 1\u00a0year mortality rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, 537 patients were hospitalised, 18 of them were receiving immunosuppressive therapy due to kidney transplantation. Baseline characteristics of the patients were broadly similar, except that smoking was reported by 22.0% of the non\u2010transplant patients and by none of the post\u2010transplant patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01). Post\u2010transplant patients tended to be younger (59.4\u00a0\u00b1\u00a011.1 vs. 65.3\u00a0\u00b1\u00a012.2;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.07), were more likely to have type\u20101 diabetes (16.7% vs. 5.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.07) and had lower glucose levels upon admission (9.4\u00a0\u00b1\u00a04.3 vs. 12.0\u00a0\u00b1\u00a06.4\u00a0mmol\/L;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.07). Overall, 30% of the patients underwent major amputation, in\u2010patient mortality rate was 9.3%, and 1\u00a0year mortality rate was 27.2%. Rates were similar in the post\u2010transplant versus the non\u2010post\u2010transplant patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.83, 1.00, 0.59, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Post\u2010transplant patients did not incur worse outcomes in spite of immunosuppressive therapy. Limb salvage efforts should be pursued in these patients similar to the overall population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3575","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T11:31:00Z","timestamp":1661772660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute diabetic foot in post kidney transplantation patients receiving chronic immunosuppression\u2014clinical presentation and outcomes"],"prefix":"10.1002","volume":"38","author":[{"given":"Kobi","family":"Gorin","sequence":"first","affiliation":[{"name":"Internal Medicine Division Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"},{"name":"The Faculty of Medicine Hebrew University  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-9994","authenticated-orcid":false,"given":"Avivit","family":"Cahn","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine Hebrew University  Jerusalem Israel"},{"name":"Department of Endocrinology and Metabolism Diabetes Unit Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Leibovitch","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine Hebrew University  Jerusalem Israel"},{"name":"Department of Military Medicine and \u2018Tzameret\u2019 Medical Corps Israel Defense Forces  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shachar","family":"Peled","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine Hebrew University  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Perzon","sequence":"additional","affiliation":[{"name":"Internal Medicine Division Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"},{"name":"The Faculty of Medicine Hebrew University  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keren","family":"Tzukert","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine Hebrew University  Jerusalem Israel"},{"name":"Department of Nephrology and Hypertension Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Haze","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine Hebrew University  Jerusalem Israel"},{"name":"Orthopedic Division Foot and Ankle Unit Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Elishoov","sequence":"additional","affiliation":[{"name":"Orthopedic Division Foot and Ankle Unit Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Olshtain\u2010Pops","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine Hebrew University  Jerusalem Israel"},{"name":"Division of Microbiology and Infectious Diseases Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yechiel Nisan","family":"Gelman","sequence":"additional","affiliation":[{"name":"The Faculty of Medicine Hebrew University  Jerusalem Israel"},{"name":"Orthopedic Division Foot and Ankle Unit Hadassah\u2010Hebrew University Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1615439"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010006\u20100491\u20101"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16\u20102189"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13054"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2319"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.10.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010008\u20100940\u20100"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3498"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019\u201000774"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u20106686.2012.00284.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10\u20101213"},{"issue":"10","key":"e_1_2_8_13_1","first-page":"651","article-title":"Hospitalizations due to acute diabetic foot: annual trends and predictors of morbidity and mortality \u2013 5\u2010years experience of a multidisciplinary unit","volume":"160","author":"Leibovitch M","year":"2021","journal-title":"Harefuah"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07\u20102244"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10\u20100255"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn724"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u2010481x.2012.00950.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346211052155"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2019.05.017"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0003\u20109993(99)90086\u20102"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.1995.tb00555.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365599609182314"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20102277.2003.tb00274.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(01)00169-6"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1056\u20108727(02)00276\u20103"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dmrr.3575","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T05:49:55Z","timestamp":1692596995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.3575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,6]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/dmrr.3575"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.3575","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/DMRR.3575\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3575\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3575\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3575\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,6]]},"assertion":[{"value":"2022-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3575"}}