{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:08:09Z","timestamp":1783944489211,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate glycaemic variability (GV) patterns in patients with type 1 diabetes (T1D), type 2 diabetes (T2D), and latent autoimmune diabetes in adults (LADA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of 842 subjects (510 T1D, 105 LADA, 227 T2D) were enrolled and underwent 1\u00a0week of continuous glucose monitoring (CGM). Clinical characteristics and CGM parameters were compared among T1D, LADA, and T2D. LADA patients were divided into two subgroups based on glutamic acid decarboxylase autoantibody titres (\u2265180\u00a0U\/mL [LADA\u20101], &lt;180\u00a0U\/mL [LADA\u20102]) and compared. The C\u2010peptide cut\u2010offs for predicting a coefficient of variation (CV) of glucose \u226536% and a time in range (TIR)\u00a0&gt;\u00a070% were determined using receiver operating characteristic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010seven patients (9 T1D, 18 T2D) were excluded due to insufficient CGM data. Sex, diabetes duration and HbA1c were comparable among the three groups. Fasting and 2\u2010h postprandial C\u2010peptide (FCP, 2hCP) increased sequentially across T1D, LADA, and T2D. T1D and LADA patients had comparable TIR and GV, whereas those with T2D had much higher TIR and lower GV (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The GV of LADA\u20101 was close to that of T1D, while the GV of LADA\u20102 was close to that of T2D. CP exhibited the strongest negative correlation with GV. The cut\u2010offs of FCP\/2hCP for predicting a CV\u00a0\u2265\u00a036% and TIR &gt;70% were 121.6\/243.1 and 128.9\/252.8\u00a0pmol\/L, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GV presented a continuous spectrum across T1D, LADA\u20101, LADA\u20102, and T2D. More frequent glucose monitoring is suggested for patients with impaired insulin secretion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trail Registration<\/jats:title>\n                    <jats:p>\n                      Chinese Clinical Trial Registration (ChiCTR) website approved by WHO;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org.cn\/\">http:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n                      \u2010 ChiCTR2200065036\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3579","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T10:13:52Z","timestamp":1665396832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The continuous spectrum of glycaemic variability changes with pancreatic islet function: A multicentre cross\u2010sectional study in China"],"prefix":"10.1002","volume":"38","author":[{"given":"Liyin","family":"Zhang","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyu","family":"Guo","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Tian","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Ye","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Ding","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieru","family":"Wu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Fan","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-6714","authenticated-orcid":false,"given":"Niansi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Heji Hospital Affiliated to Changzhi Medical College  Changzhi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Heji Hospital Affiliated to Changzhi Medical College  Changzhi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Luoyang Clinical Medicine Research Center of Endocrine and Metabolic Diseases  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Ma","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Luoyang Clinical Medicine Research Center of Endocrine and Metabolic Diseases  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Luoyang Clinical Medicine Research Center of Endocrine and Metabolic Diseases  Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7361-6231","authenticated-orcid":false,"given":"Gan","family":"Huang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4451-4906","authenticated-orcid":false,"given":"Zhiguang","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291401"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002103420603"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0806470"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.16107"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17\u20100636"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17\u20101600"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010012\u20102816\u20106"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08\u20100864"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20103604"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13306"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010018\u20100677\u20100"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20100823"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00644"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3092"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac034"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.06.003"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.2.359"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12\u20100931"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i19.2900"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12\u20100207"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07\u20100299"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20101032"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1447.036"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0388"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096\u20109136(199807)15:7<539::aid\u2010dia668>3.0.co;2\u2010s"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2779"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3407"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3047"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010019\u20100952\u20108"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201083599\u2010x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.108933"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.108839"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00281310"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753\u20100407.12907"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-128-7-199804010-00001"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11\u20102190"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.02.003"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010020\u201005099\u20103"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201088749\u20109"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108152"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12957"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12216"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13426"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010020\u201001634\u20101"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dmrr.3579","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T05:49:53Z","timestamp":1692596993000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.3579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/dmrr.3579"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.3579","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/DMRR.3579\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3579\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3579\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3579\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3579\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3579\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3579\/v2\/review1","asserted-by":"object"}]},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,25]]},"assertion":[{"value":"2022-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3579"}}