{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:05:11Z","timestamp":1778893511669,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Type 2 diabetes mellitus (T2DM) frequently co\u2010exists with osteoporosis and dyslipidemia. Statins have been commonly used in the treatment of dyslipidemia. Recent studies have indicated a therapeutic role of statins in decreasing the risk of osteoporosis and fractures, but conflicting results have been reported. This study investigated the association between statin use and hip fracture (HFx) risk among T2DM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective Taiwan population\u2010based propensity\u2010matched cohort study was performed using the Diabetes Mellitus Health Database from Taiwan National Health Insurance Research Database. Patients with newly diagnosed with T2DM between 2010 and 2014 were identified. Patients who previously used statins and had ever suffered HFx before the index date were excluded. HFx that occurred from 2010 to 2019 was collected to compute the cumulative rate of HFx. Hazard ratios (HRs) were calculated for the HFx risk according to the use or non\u2010use of statins. To evaluate the dose\u2013effect relationship of statins, sensitivity analyses were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After propensity score matching for age and sex, 188,588 patients were identified as statin users and non\u2010statin users. Statin use after T2DM diagnosis was associated with a decreased HFx risk with an adjusted HR (aHR) of 0.69 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). A dose\u2013effect relationship was identified. The aHRs for developing HFx were 1.29, 0.67, and 0.36 for patients who used 28\u2013174, 175\u2013447, and &gt;447 cumulative defined daily doses of statins, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Statin use in adults with T2DM showed a lower risk of HFx by demonstrating a dose\u2013response relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3603","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T06:10:16Z","timestamp":1672294216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Statin use in patients with type 2 diabetes has lower risk of hip fractures: A Taiwan national population\u2010based study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-8079","authenticated-orcid":false,"given":"Tien\u2010Ching","family":"Lee","sequence":"first","affiliation":[{"name":"Graduate Institute of Medicine College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Orthopaedic Research Center College of Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Orthopedics College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Orthopedics Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010Chih","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics College of Medicine Kaohsiung 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