{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:39:07Z","timestamp":1781285947312,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We investigated whether Diabetic Retinopathy (DR) is related to Diabetic Foot Ulcer (DFU) development, adjusted for the stratification of the International Work Group on Diabetic Foot (IWGDF) guidance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>DR and IWGDF stratification was registered retrospectively in patients hospitalised from 2009 to 2017 for uncontrolled and\/or complicated type 2 diabetes. New DFUs were registered until 2020. Survival analyses categorised the subjects for DR, and multivariate Cox regression adjusted for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 522 patients (57.9% male) were 62\u00a0\u00b1\u00a09\u00a0years old with a diabetes duration of 14\u00a0\u00b1\u00a010\u00a0years, HbA1c of 8.7\u00a0\u00b1\u00a01.8%, 33.9% macroangiopathies and 44.8% diabetic kidney diseases. Their grades of DFU risk were 0 for 43.3%, 1 for 23.9%, 2 for 7.1%, and 3 for 25.6%. During the 52\u00a0months follow\u2010up (Inter Quartile Range: 32\u201371), 58 new DFUs and 18 lower\u2010limb amputations occurred, mostly in patients with DR present in 140 (26.8%) patients. Adjusted for age, sex and conventional risk factors (duration and control of diabetes, arterial hypertension, and dyslipidemia), and other complications (macroangiopathy and diabetic kidney disease), DR was associated with a greater incidence of DFUs. Adjusted for the IWGDF classification, DR was related to new DFUs (HR: 2.51, 95%Confidence Interval [CI]: 1.48\u20134.26) and amputations (HR: 3.56, 95%CI: 1.26\u201310.07). This relationship persisted in ascending IWGDF grades with incidences of DFUs from 2\/1000 (grade 0, no DR) to 121\/1000 patient\u2010years (grade 3 and DR) and amputations from 0 (grade 0, no DR) to 38\/1000 patient\u2010years (grade 3 and DR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diabetic retinopathy independently relates to the incidence of foot ulcers and amputations in patients hospitalised for type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3605","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T01:43:45Z","timestamp":1672191825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Diabetic retinopathy relates to the incidence of foot ulcers and amputations in type 2 diabetes"],"prefix":"10.1002","volume":"39","author":[{"given":"Gauthier","family":"Borderie","sequence":"first","affiliation":[{"name":"Endocrinology\u2010Diabetology\u2010Nutrition Bordeaux CHU and University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninon","family":"Foussard","sequence":"additional","affiliation":[{"name":"Endocrinology\u2010Diabetology\u2010Nutrition Bordeaux CHU and University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Larroumet","sequence":"additional","affiliation":[{"name":"Endocrinology\u2010Diabetology\u2010Nutrition Bordeaux CHU and University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Blanco","sequence":"additional","affiliation":[{"name":"Endocrinology\u2010Diabetology\u2010Nutrition Bordeaux CHU and University  Bordeaux 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