{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:07:05Z","timestamp":1772118425521,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013104","name":"Shanghai Health and Medical Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate whether intermittently scanned continuous glucose monitoring without alarms (intermittently scanned CGM (isCGM)) improves glycaemic control over capillary blood glucose monitoring (BGM) among adult type 1 diabetes mellitus (T1DM) patients with suboptimal control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Adults with T1DM and HbA1c between 7% and 10% were 1:1 randomized to use isCGM or BGM for 24\u00a0weeks. The primary outcome was the change in HbA1c levels after intervention. The secondary outcomes were the changes in sensor\u2010derived metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 104 adults with T1DM (34.2\u00a0\u00b1\u00a012.2\u00a0years; M\/F, 38\/66) were randomized to the isCGM group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a054) and the BGM group (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a050). After 24\u00a0weeks, HbA1c significantly decreased in the isCGM group (8.1\u00a0\u00b1\u00a00.7% to 7.5\u00a0\u00b1\u00a01.0%) and the BGM group (8.0\u00a0\u00b1\u00a00.8% to 7.7\u00a0\u00b1\u00a01.0%) with between\u2010group differences of 0.3% (95% coefficient intervals, 0.0%\u20130.6%;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.04). The percentage of HbA1c reduction over 1.0% and 1.5% was significantly higher in the isCGM group with adjusted odds ratios of 2.5 (95% CI: 1.1\u20135.5;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03) and 3.2 (95% CI: 1.1\u20139.0;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.03). Mean time\u2010in\u2010range 70\u2013180\u00a0mg\/dl (TIR) in the isCGM group significantly increased (from 58.5\u00a0\u00b1\u00a013.0% to 63.0\u00a0\u00b1\u00a012.6%), whereas mean TIR was similar in the BGM group (from 58.0\u00a0\u00b1\u00a014.6% to 57.5\u00a0\u00b1\u00a014.5%). Time spent in hyperglycemia reduced more in the isCGM group and time spent in hypoglycemia did not change significantly in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among adult T1DM patients with suboptimal glycaemic control, compared with BGM, isCGM use resulted in a statistically significant improvement in glycaemic control after 24\u2010week intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinicaltrials.gov Identifier (NCT03522870)<\/jats:p>\n                  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of Chinese Academy of Sciences (Hefei) University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Institute of Endocrine and Metabolic Diseases The First Affiliated Hospital of USTC Division of Life Sciences and Medicine Clinical Research Hospital of Chinese Academy of Sciences (Hefei) University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihui","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Institute of Endocrine and Metabolic Diseases The First Affiliated Hospital 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