{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:52:11Z","timestamp":1779238331261,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060076"],"award-info":[{"award-number":["82060076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elevated glucose levels at admission are associated with a worse prognosis in patients with acute myocardial infarction (AMI); additionally, such elevation has a higher prognostic value for patients without diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively recruited 2412 AMI patients without diabetes from 1 August 2011 to 10 January 2022. The primary outcome was all\u2010cause mortality during hospitalisation, and the secondary outcomes were cardiogenic shock, ventricular tachycardia, ventricular fibrillation, atrioventricular block and new stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of participants was 65\u00a0years and 78.6% were male. Of the 2412 patients, all\u2010cause mortality occurred in 236 patients (9.8%) during hospitalisation. In multivariate\u2010adjusted models that corrected for variable weights, the risk of all\u2010cause mortality increased with an increase in random glucose levels at admission; specifically, the risk of all\u2010cause mortality increased per 1\u00a0mg\/dL (odds ratio [OR] 1.006, 95% confidence interval\u00a0[CI]: 1.004\u20131.008), per 9\u00a0mg\/dL (OR: 1.06, 95% CI: 1.04\u20131.08), and per 18\u00a0mg\/dL (OR: 1.12, 95% CI: 1.07\u20131.16) increases in admission glucose levels. When admission glucose levels were expressed as a categorical variable, increased levels of glucose (relative to the reference glucose value\u00a0&lt;140\u00a0mg\/dL) led to an increased risk of all\u2010cause mortality; specifically, the OR of all\u2010cause mortality for 140\u2013200\u00a0mg\/dL glucose was 1.55 (95% CI: 1.09\u20132.17) and the OR for glucose &gt;200\u00a0mg\/dL was 3.08 (95% CI: 2.00\u20134.62) (\n                      <jats:italic>P<\/jats:italic>\n                      for trend &lt;0.001). The risk of cardiogenic shock also increased with glucose levels with an OR of 1.68 (95% CI: 1.21\u20132.31) for 140\u2013200\u00a0mg\/dL glucose and an OR of 3.72 (95% CI: 2.50\u20135.46) for &gt;200\u00a0mg\/dL, compared with that of glucose &lt;140\u00a0mg\/dL. In multivariate\u2010adjusted spline regression models, an increased risk of all\u2010cause mortality was observed in patients with glucose \u2265122\u00a0mg\/dL (OR: 1.81, 95% CI: 1.38\u20132.38,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) compared with the reference cohort. Furthermore, patients with glucose \u2265111\u00a0mg\/dL (OR: 2.36, 95% CI: 1.80\u20133.12) had a higher risk of cardiogenic shock than patients with glucose &lt;111\u00a0mg\/dL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with AMI and without diabetes who had elevated random glucose levels at admission had a higher risk of all\u2010cause mortality and cardiogenic shock during hospitalisation. In particular, patients with glucose \u2265122\u00a0mg\/dL had an increased risk of all\u2010cause mortality, and those with glucose \u2265111\u00a0mg\/dL had an increased risk of cardiogenic shock.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3617","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T10:44:25Z","timestamp":1675334665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Elevated random glucose levels at admission are associated with all\u2010cause mortality and cardiogenic shock during hospitalisation in patients with acute myocardial infarction and without diabetes: A retrospective cohort study"],"prefix":"10.1002","volume":"39","author":[{"given":"Yujuan","family":"Yuan","sequence":"first","affiliation":[{"name":"People's Hospital of Xinjiang Uygur Autonomous Region  Xinjiang 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