{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:55:32Z","timestamp":1788717332466,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the impact of assisted reproductive technology (ART) on the risk of gestational diabetes mellitus (GDM) in single pregnancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We retrospectively collected clinical and anthropometric data of 219ART\u2010 and 256 age\u2010 and body mass index (BMI)\u2010matched women with spontaneous conception screened for GDM. The primary outcome was to evaluate GDM prevalence in ART women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no differences in age, BMI, and family history of diabetes in the two groups of women. ART\u2010women were more frequently primiparous, whereas the prevalence of previous GDM was higher in SC\u2010women. The prevalence of GDM in the\u00a0whole cohort was 36.1% and was higher in ART\u2010women (52.3% vs. 23.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). In the whole cohort, on multivariate analysis, family history of diabetes (OR 1.67; 95% CI: 1.03\u20132.69), previous GDM (OR 7.05; 95% CI: 2.92\u201317.04), pre\u2010pregnancy obesity (OR 2.72; 95% CI 1.21\u20136.13), and ART (OR 4.14; 95% CI 2.65\u20136.48) were independent risk factors for GDM. Among ART\u2010women, age over 40\u00a0years was associated with GDM. Preterm delivery was more common in ART\u2010women; gestational week at delivery, birth weight, ponderal index, and Apgar score were lower in ART\u2010women than in SC\u2010women, both in the whole cohort and in GDM women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among women undergoing ART treatment, at least one in two develops GDM. ART appears to be an independent risk factor for GDM in single pregnancies, particularly above the age of 40. ART treatment seems to be associated with an increased rate of preterm delivery and lower neonatal birth weight and Apgar score, especially in GDM women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>The study was not registered as it is an observational retrospective evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3625","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T21:28:30Z","timestamp":1676928510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Assisted reproductive technology, risk of gestational diabetes, and perinatal outcomes in singleton pregnancies"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2799-2380","authenticated-orcid":false,"given":"Cristina","family":"Bianchi","sequence":"first","affiliation":[{"name":"Department of Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-2804","authenticated-orcid":false,"given":"Alex","family":"Brocchi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4532-3028","authenticated-orcid":false,"given":"Walter","family":"Baronti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Nicol\u00ec","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizia","family":"Citro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Aragona","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Cela","sequence":"additional","affiliation":[{"name":"Maternal\u2010Infant Department University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Del Prato","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bertolotto","sequence":"additional","affiliation":[{"name":"Department of Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.09.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2014.02.009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958\u2010016\u20100211\u20108"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1670790"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa011"},{"issue":"6","key":"e_1_2_10_7_1","first-page":"885","article-title":"Gestational diabetes in IVF and spontaneous pregnancies","volume":"32","author":"Szymanska M","year":"2011","journal-title":"Neuro Endocrinol Lett"},{"key":"e_1_2_10_8_1","unstructured":"AMD\u2010SID.Standard Italiani per la cura del Diabete Mellito. 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