{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:07:26Z","timestamp":1772118446997,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>In the Sars\u2010Cov\u20102 pandemic era, patients with diabetes mellitus (DM) manifested more severe forms of Sars\u2010Cov\u20102 with greater mortality than non\u2010diabetic patients. Several studies documented more aggressive forms of diabetic foot ulcers (DFU) during the pandemic period even though the results were not unanimously confirmed. The aim of this study was to evaluate the clinical\u2010demographic differences between a cohort of Sicilian diabetic patients hospitalised for DFU in the pre\u2010pandemic 3\u00a0years and a cohort of patients hospitalised in the pandemic 2\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>One hundred and eleven patients from the pre\u2010pandemic period 2017\u20132019 (Group A) and 86 patients from the pandemic period 2020\u20132021 (Group B) with DFU, admitted to the division of Endocrinology and Metabolism of the University Hospital of Palermo, were retrospectively evaluated. The clinical assessment of the type, staging and grading of the lesion, and the infective complication from DFU was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No differences in HbA1c values were observed between the two groups. Group B showed a significantly higher prevalence of male subjects (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.010), neuro\u2010ischaemic ulcers (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), deep ulcers with involvement of bones (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), white blood count levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), and reactive C protein (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001) compared to group A.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data show that in the COVID\u201019 pandemic, a greater severity of ulcers requiring a significantly greater number of revascularisations and more expensive therapy, but without an increase in the amputation rate, was observed. These data provide novel information on the impact of the pandemic on diabetic foot ulcer risk and progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3626","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T23:09:28Z","timestamp":1677107368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evidence of greater severity of diabetic foot ulcers during COVID\u201019 pandemic: A real\u2010life single\u2010centre cohort study"],"prefix":"10.1002","volume":"39","author":[{"given":"Stefano","family":"Radellini","sequence":"first","affiliation":[{"name":"Section of Endocrinology, Diabetology and Metabolism Dipartimento di Promozione della Salute Materno\u2010Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d (PROMISE) Division of \u201cMalattie Endocrine, del Ricambio e della Nutrizione\u201d Universit\u00e0 degli studi di Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica","family":"Vigneri","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetology and Metabolism Dipartimento di Promozione della Salute Materno\u2010Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d (PROMISE) Division of \u201cMalattie Endocrine, del Ricambio e della Nutrizione\u201d Universit\u00e0 degli studi di Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Smeraldi","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetology and Metabolism Dipartimento di Promozione della Salute Materno\u2010Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d (PROMISE) Division of \u201cMalattie Endocrine, del Ricambio e della Nutrizione\u201d Universit\u00e0 degli studi di Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettore","family":"Dinoto","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Oral Sciences Vascular Surgery Unit AOUP Policlinico \u2018P. Giaccone\u2019 University of Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Guercio","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncological and Stomatological Disciplines Division of Surgery University of Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierina","family":"Richiusa","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetology and Metabolism Dipartimento di Promozione della Salute Materno\u2010Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d (PROMISE) Division of \u201cMalattie Endocrine, del Ricambio e della Nutrizione\u201d Universit\u00e0 degli studi di Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero Luigi","family":"Almasio","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology Dipartimento di Promozione della Salute Materno\u2010Infantile Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d PROMISE Universit\u00e0 degli Studi di Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Guarnotta","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetology and Metabolism Dipartimento di Promozione della Salute Materno\u2010Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d (PROMISE) Division of \u201cMalattie Endocrine, del Ricambio e della Nutrizione\u201d Universit\u00e0 degli studi di Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Salzillo","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetology and Metabolism Dipartimento di Promozione della Salute Materno\u2010Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d (PROMISE) Division of \u201cMalattie Endocrine, del Ricambio e della Nutrizione\u201d Universit\u00e0 degli studi di Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1731-9395","authenticated-orcid":false,"given":"Carla","family":"Giordano","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetology and Metabolism Dipartimento di Promozione della Salute Materno\u2010Infantile, di Medicina Interna e Specialistica di Eccellenza \u201cG. D\u2019Alessandro\u201d (PROMISE) Division of \u201cMalattie Endocrine, del Ricambio e della Nutrizione\u201d Universit\u00e0 degli studi di Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2020.09.028"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3377"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108142"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2020.05.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010020\u201001236\u20102"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa146"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2020.08.018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300\u2010021\u201001114\u2010x"},{"key":"e_1_2_10_10_1","first-page":"1","article-title":"Telemedicine for the clinical management of diabetes; implications and considerations after COVID\u201019 experience","volume":"17","author":"Kreutzenberg SV","year":"2022","journal-title":"High Blood Press Cardiovasc Prev"},{"key":"e_1_2_10_11_1","first-page":"30","article-title":"Diabetic foot and COVID\u201019. 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