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Non\u2010coding RNAs (ncRNAs), including microRNAs (miRNAs), long non\u2010coding RNAs (lncRNAs), and circular RNAs (circRNAs), play essential roles in various biological functions in the hyperglycaemic environment that determines the development of DFU. Ulceration results in tissue breakdown and skin barrier scavenging, thereby facilitating bacterial infection and biofilm formation. Many bacteria contribute to diabetic foot infection (DFI), including <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:italic>S<\/jats:italic>. <jats:italic>aureus<\/jats:italic>) et\u00a0al. A heterogeneous group of \u201cncRNAs,\u201d termed small RNAs (sRNAs), powerfully regulates biofilm formation and DFI healing. Multidisciplinary foot care interventions have been identified for nonhealing ulcers. With an appreciation of the link between disease processes and ncRNAs, a novel therapeutic model of bioactive materials loaded with ncRNAs has been developed to prevent and manage diabetic foot complications.<\/jats:p>","DOI":"10.1002\/dmrr.3740","type":"journal-article","created":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T13:39:16Z","timestamp":1697377156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Non\u2010coding RNAs in diabetic foot ulcer\u2010 a focus on infected wounds"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-5278","authenticated-orcid":false,"given":"Boquan","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute Laboratory of Stem Cell and Tissue Engineering State Key Laboratory of Biotherapy West China Hospital Sichuan University  Chengdu 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