{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:22:54Z","timestamp":1777584174669,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100822"],"award-info":[{"award-number":["82100822"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore the relationship between preconception severe hypoglycemia (PSH) and pregnancy outcomes in pregnancies complicated with type 1 diabetes mellitus (T1DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this multicenter prospective cohort study, women with pregestational T1DM were stratified by episodes of severe hypoglycemia within 1\u00a0year before conception: No PSH, sporadic PSH (1\u20136 times\/year), and recurrent PSH (&gt;6 times\/year). We analysed the predictive ability of PSH for maternal and neonatal outcomes using log\u2010binomial regression models and receiver operating characteristic (ROC) curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 124 women studied, 37.1% experienced at least one episode of severe hypoglycemia preconception. In the multiple adjusted regression models, recurrent PSH was significantly associated with increased incidence of preeclampsia (RR 17.59, 95% CI: 2.89\u2013150.62,\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u00a0=\u00a00.007), preterm birth (RR 6.34, 95% CI: 1.22\u201340.63,\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u00a0=\u00a00.027), neonatal hypoglycemia (RR 4.52, 95% CI: 1.14\u201317.16,\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u00a0=\u00a00.017), neonatal hyperbilirubinemia (RR 4.12, 95% CI: 1.11\u201315.56,\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u00a0=\u00a00.004), and composite neonatal outcome (RR 3.85, 95% CI: 1.01\u201319.61,\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u00a0=\u00a00.003). In the ROC analysis, PSH predicted preeclampsia, preterm birth, neonatal hypoglycemia, neonatal hyperbilirubinemia, and composite neonatal outcome with areas under the ROC curve all \u22650.6.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recurrent preconception severe hypoglycemia is associated with increased risks of adverse outcomes in pregnant women with T1DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3741","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T01:06:25Z","timestamp":1698195985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preconception episodes of severe hypoglycemia and risk of adverse pregnancy outcomes in pregnant women with type 1 diabetes mellitus"],"prefix":"10.1002","volume":"40","author":[{"given":"Yixin","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Endocrinology Zhongda Hospital Institute of Diabetes School of Medicine Southeast University  Nanjing China"},{"name":"Department of Endocrinology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihui","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Zhongda Hospital Institute of Diabetes School of Medicine Southeast University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of USTC University of Science and Technology of China  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daizhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Zhongda Hospital Institute of Diabetes School of Medicine Southeast University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Zhongda Hospital Institute of Diabetes School of Medicine Southeast University  Nanjing 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