{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:34:18Z","timestamp":1791844458373,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Ketosis\u2010prone type 2 diabetes was defined by the World Health Organization in 2019. According to the literature, the diagnosis is based on the presence of ketosis, islet autoantibody negativity and preserved insulin secretion. Our meta\u2010analysis assessed the prevalence and clinical characteristics of ketosis\u2010prone type 2 diabetes among patients hospitalised with diabetic ketoacidosis (DKA) or ketosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The systematic search was performed in five main databases as of 15 October 2021 without restrictions. We calculated the pooled prevalence of ketosis\u2010prone type 2 diabetes (exposed group) within the diabetic population under examination, patients with ketoacidosis or ketosis, to identify the clinical characteristics, and we compared it to type 1 diabetes (the comparator group). The random effects model provided pooled estimates as prevalence, odds ratio and mean difference (MD) with 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eleven articles were eligible for meta\u2010analysis, thus incorporating 2010 patients of various ethnic backgrounds. Among patients presenting with DKA or ketosis at the onset of diabetes, 35% (95% CI: 24%\u201349%) had ketosis\u2010prone type 2 diabetes. These patients were older (MD\u00a0=\u00a011.55\u00a0years; 95% CI: 5.5\u201317.6) and had a significantly higher body mass index (BMI) (MD\u00a0=\u00a05.48\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; 95% CI: 3.25\u20137.72) than those with type 1 diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ketosis\u2010prone type 2 diabetes accounts for one third of DKA or ketosis at the onset of diabetes in adults. These patients are characterised by islet autoantibody negativity and preserved insulin secretion. They are older and have a higher BMI compared with type 1 diabetes. C\u2010peptide and diabetes\u2010related autoantibody measurement is essential to identify this subgroup among patients with ketosis at the onset of diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3743","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T08:18:42Z","timestamp":1698394722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["One third of cases of new\u2010onset diabetic ketosis in adults are associated with ketosis\u2010prone type 2 diabetes\u2014A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4564-2739","authenticated-orcid":false,"given":"Adrienn","family":"Kovacs","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Hematology Semmelweis University  Budapest Hungary"},{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bunduc","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute of Pancreatic Diseases Semmelweis University  Budapest Hungary"},{"name":"Carol Davila University of Medicine and Pharmacy  Bucharest Romania"},{"name":"Fundeni Clinical Institute  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Veres","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Biophysics and Radiation Biology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Palinkas","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Department of Gastroenterology Military Hospital\u2014State Health Centre  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre B.","family":"Gagyi","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Selye Janos Doctoral College for Advanced Studies Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute of Pancreatic Diseases Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balint","family":"Eross","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute of Pancreatic Diseases Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emese","family":"Mihaly","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Hematology Semmelweis University  Budapest Hungary"},{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"},{"name":"Institute of Pancreatic Diseases Semmelweis University  Budapest Hungary"},{"name":"Institute for Translational Medicine Medical School University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Hosszufalusi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Hematology Semmelweis University  Budapest Hungary"},{"name":"Centre for Translational Medicine Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010050219\u2010034524"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23\u2010S002"},{"key":"e_1_2_11_4_1","unstructured":"Geneva: World Health Organization.Classification of Diabetes Mellitus;2019. 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