{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:49:47Z","timestamp":1792183787313,"version":"4.4.0"},"reference-count":89,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The 1989 Saint Vincent Declaration established a goal of halving global diabetes\u2010related amputation rates. A generation later, this goal has been achieved for major but not minor amputations. However, diabetic foot disease (DFD) is not only a leading cause of global amputation but also of hospitalisation, poor quality of life (QoL) and disability burdens. In this paper, we review latest estimates on the global disease burden of DFD and the next generation care of DFD that could reduce this burden. We found DFD causes 2% of the global disease burden. This makes DFD the 13\n                    <jats:sup>th<\/jats:sup>\n                    largest of 350+ leading conditions causing the global disease burden, and much larger than dementia, breast cancer and type 1 diabetes. Neuropathy\n                    <jats:italic>without<\/jats:italic>\n                    ulcers and amputations makes up the largest portion of the global DFD burden yet receives the least DFD focus. Future care focussed on improving safe physical activity in people with DFD could considerably reduce the DFD burden, as this incorporates increasing physical fitness and QoL, while simultaneously decreasing ulceration and other risks. Charcot neuro\u2010osteoarthropathy is more prevalent than previously thought. Most cases respond well to non\u2010removable offloading devices, but surgical intervention may further reduce the considerable burden of these neuropathic fracture dislocations. Ischaemia is becoming more common and complex. Most cases respond well to revascularisation interventions, but novel revascularisation techniques, medical management and autologous cell therapies may hold the key to more cases responding in the future. We conclude that DFD causes a global disease burden larger than most conditions and existing guideline\u2010based care and next generation treatments can reduce this burden. We suggest the World Health Organization and International Diabetes Federation declare a new goal: halving the global DFD burden from 2% to 1% within the next generation.\n                  <\/jats:p>","DOI":"10.1002\/dmrr.3747","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T20:56:25Z","timestamp":1700859385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["A new declaration for feet's sake: Halving the global diabetic foot disease burden from 2% to 1% with next generation care"],"prefix":"10.1002","volume":"40","author":[{"given":"Peter A.","family":"Lazzarini","sequence":"first","affiliation":[{"name":"School of Public Health and Social Work Queensland University of Technology  Brisbane Queensland Australia"},{"name":"Allied Health Research Collaborative The Prince Charles Hospital  Brisbane Queensland 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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1615439"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(05)67698\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-7560(200009\/10)16:1 <::AID-DMRR113>3.0.CO;2-S"},{"issue":"232","key":"e_1_2_10_5_1","first-page":"763","article-title":"Improved survival of the diabetic foot: the role of a specialized foot clinic","volume":"60","author":"Edmonds ME","year":"1986","journal-title":"Q J Med"},{"issue":"4","key":"e_1_2_10_6_1","first-page":"360","article-title":"Diabetes care and research in Europe","volume":"7","year":"1990","journal-title":"Saint Vincent 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