{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:49:33Z","timestamp":1781322573489,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Insulin requirement in women with Type 1 diabetes (T1DM) changes throughout pregnancy. The aim of this study was to determine the total change in insulin requirements and the effect of gestational weight gain (GWG) and pre\u2010gestational BMI on insulin requirements during pregnancy in women with T1DM treated with continuous subcutaneous insulin infusion and continuous glucose monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This historical cohort study included all consecutive women with T1DM who were monitored during pregnancy at the high\u2010risk pregnancy clinic at a tertiary medical center during April 2011\u2013April 2019. One Way Repeated Measures ANOVA with Bonferroni adjustment was conducted to compare the effects of gestational age on insulin requirements and a Two Way Repeated Measures ANOVA was employed to test for the interaction between gestational age intervals and maternal BMI and GWG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data regarding insulin requirements of 185 pregnancies were included in the analyses. There was a significant effect of gestational age on total insulin (Wilks' Lambda\u00a0=\u00a00.34, F(6,14)\u00a0=\u00a04.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009), basal insulin (Wilks' Lambda\u00a0=\u00a00.41, F(6,14)\u00a0=\u00a03.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.031) and bolus insulin (Wilks' Lambda\u00a0=\u00a00.43, F(6,14)\u00a0=\u00a03.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.041). Total insulin\/kg requirements increased by 5.5% from 13\u201320\u00a0weeks to 20\u201326\u00a0weeks, 19% from 20\u201326\u00a0weeks to 26\u201333\u00a0weeks, and 17.4% from 26 to 33\u00a0weeks to delivery (\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u00a0=\u00a00.009). Overall, insulin requirements increased by 42.1% from conception to delivery (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01).\n                    <\/jats:p>\n                    <jats:p>There was no significant main effect of maternal BMI or GWG on insulin requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is a significant increase in insulin requirements per kg during pregnancy in women with T1DM who were treated with an insulin pump.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3771","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T01:19:23Z","timestamp":1708910363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Insulin requirements during pregnancy in women with type 1 diabetes treated with insulin pump"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6866-4039","authenticated-orcid":false,"given":"Nimrod","family":"Dori\u2010Dayan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Cukierman\u2010Yaffe","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Endocrinology Department Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni","family":"Zemet","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohad","family":"Cohen","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Endocrinology Department Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Levi","sequence":"additional","affiliation":[{"name":"Endocrinology Department Sheba Medical Center  Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shali","family":"Mazaki\u2010Tovi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakefet","family":"Yoeli\u2010Ullman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(91)90012\u2010g"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010009\u20101633\u2010z"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.7.1130"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20100528.1998.tb10207.x"},{"issue":"2","key":"e_1_2_12_6_1","first-page":"253","article-title":"Insulin requirements during pregnancy in women with type I diabetes","volume":"83","author":"Steel JM","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.15.10.1323"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495x13516442"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5320156"},{"key":"e_1_2_12_10_1","volume-title":"Weight Gain during Pregnancy: Reexamining the Guidelines","author":"Council NR","year":"2010"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000425668.87506.4c"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3300"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010019\u201001326\u20105"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2015.0165"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20101437"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14039"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd005542.pub3"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2016.0412"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(17)32400\u20105"},{"issue":"3","key":"e_1_2_12_20_1","first-page":"137","article-title":"Towards implementation of the saint vincent declaration: outcomes of women with pregestational diabetes","volume":"22","author":"Yoeli\u2010Ullman R","year":"2020","journal-title":"Isr Med Assoc J IMAJ"},{"issue":"5","key":"e_1_2_12_21_1","first-page":"311","article-title":"Birth weight standards in the live\u2010born population in Israel","volume":"7","author":"Dollberg S","year":"2005","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2016.11.013"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38043.583160.ee"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09\u20100656"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010017\u20104314\u20103"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.837444"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340\u2010018\u20100369\u20108"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11\u20102467"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20100859"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018\u201000094"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.610877"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.07.030"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000000271"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18\u20100551"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.7.2207"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176157"},{"issue":"9","key":"e_1_2_12_37_1","article-title":"Study of insulin resistance in subclinical hypothyroidism","volume":"4","author":"Vyakaranam S","year":"2014","journal-title":"Int J Health Sci Res"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051022"},{"key":"e_1_2_12_40_1","first-page":"589","article-title":"Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids","volume":"5","author":"Lupton JR","year":"2002","journal-title":"Natl Acad Press Wash DC USA"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:39:09Z","timestamp":1758083949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.3771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,25]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/dmrr.3771"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.3771","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/DMRR.3771\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3771\/v4\/response1","asserted-by":"object"}]},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,25]]},"assertion":[{"value":"2022-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3771"}}