{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:22:58Z","timestamp":1778073778703,"version":"3.51.4"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The effectiveness of sodium\u2010glucose co\u2010transporter\u20102 inhibitors (SGLT2i) on incident dementia in patients with diabetes and atrial fibrillation (AF) remains unknown. This study aimed to investigate the association between SGLT2i and the risk of incident dementia in diabetic patients with AF, and to explore the interactions with oral anticoagulants or dipeptidyl peptidase\u20104 inhibitors (DPP4i).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a cohort study using Taiwan's National Health Insurance Research Database. Patients with diabetes and AFwithout a prior history of established cardiovascular diseases, were identified. Using propensity score matching, 810 patients receiving SGLT2i were matched with 1620 patients not receiving SGLT2i. The primary outcome was incident dementia, and secondary outcomes included composite cardiovascular events and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After up to 5\u00a0years of follow\u2010up, SGLT2i use was associated with a significantly lower risk of incident dementia (hazard: 0.71, 95% confidence interval: 0.51\u20130.98), particularly vascular dementia (HR: 0.44, 95% CI: 0.24\u20130.82). SGLT2i was related to reduced risks of AF\u2010related hospitalisation (HR: 0.72, 95% CI: 0.56\u20130.93), stroke (HR: 0.75, 95% CI: 0.60\u20130.94), and all\u2010cause death (HR: 0.33, 95% CI: 0.24\u20130.44). The protective effects were consistent irrespective of the concurrent use of non\u2010vitamin K antagonist oral anticoagulants (NOACs) or DPP4i.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In diabetic patients with AF, SGLT2i was associated with reduced risks of incident dementia, AF\u2010related hospitalisation, stroke, and all\u2010cause death. The protective effects were independent of either concurrent use of NOACs or DPP4i.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3775","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T08:43:15Z","timestamp":1707554595000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The impact of sodium\u2010glucose co\u2010transporter\u20102 inhibitors on dementia and cardiovascular events in diabetic patients with atrial fibrillation"],"prefix":"10.1002","volume":"40","author":[{"given":"Yun\u2010Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine and College of Life Sciences National Chung Hsing University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao\u2010Chih","family":"Chang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Medicine Taipei Veterans General Hospital Taoyuan Branch  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yenn\u2010Jiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Faculty of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Liong","family":"Chien","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6218-7139","authenticated-orcid":false,"given":"Yu\u2010Cheng","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Cardiovascular Center Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa\u2010Po","family":"Chung","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Faculty of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Heng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Research Taichung Veterans General Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y. 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