{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:30:47Z","timestamp":1784903447295,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Previous studies have found that a single liver enzyme may predict gestational diabetes mellitus (GDM), but the results have been inconsistent. This study aimed to explore the associations of liver enzymes in early pregnancy with risk of GDM, as well as to independently rank risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study included 1295 women who underwent liver enzyme measurements during early pregnancy and completed GDM assessment in mid\u2010pregnancy. Logistic regression and restricted cubic spline analyses were conducted to assess the relationship between liver enzymes and risk of GDM. Back\u2010propagation artificial neural network was performed to rank independently risk factors of GDM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women diagnosed with GDM exhibited significantly higher levels of liver enzymes than those without GDM (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). The highest quartile of liver enzymes was associated with higher risk of GDM compared with the lowest quartile, with adjusted odds ratio (\n                      <jats:italic>ORs<\/jats:italic>\n                      ) ranging from 2.76 to 8.11 (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Moreover, the\n                      <jats:italic>ORs<\/jats:italic>\n                      of GDM increased linearly with liver enzymes level (all\n                      <jats:italic>P<\/jats:italic>\n                      for overall association &lt;0.001). Furthermore, Back\u2010propagation artificial neural network identified \u03b3\u2010gamma\u2010glutamyl transferase (GGT) as accounting for the highest proportion in the ranking of GDM risk prediction weights (up to 20.8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Single or total elevations of liver enzymes in early pregnancy could predict the GDM occurrence, in which GGT, alkaline Phosphatase, and aspartate aminotransferase were the three most important independent risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3799","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T08:04:21Z","timestamp":1711613061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Elevated liver enzymes in the first trimester are associated with gestational diabetes mellitus: A prospective cohort study"],"prefix":"10.1002","volume":"40","author":[{"given":"Lingling","family":"Cui","sequence":"first","affiliation":[{"name":"College of Public Health Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Public Health Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqian","family":"Li","sequence":"additional","affiliation":[{"name":"College of Public Health Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Public Health Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengya","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Public Health Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8099-076X","authenticated-orcid":false,"given":"Xinxin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Public Health Zhengzhou University  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.09.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010019\u20100098\u20108"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12854"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1361"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002926"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13221"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1197373"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201004631\u20107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11\u20100919"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.05.025"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10\u20101806"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010023\u201002818\u20106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.17117"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592\u2010019\u201001458\u20108"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14759"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27291"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010019\u201001954\u20105"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09\u20101848"},{"key":"e_1_2_10_20_1","volume-title":"Diagnostic Criteria and Classification of Hyperglycaemia First Detected in Pregnancy","author":"Organization GWH","year":"2013"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13\u20102229"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00581"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13558"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2020.35.e198"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1017448"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijgm.s332946"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161304"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201098180\u20109"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2015.0106"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.3.344"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010018\u20104779\u20108"},{"issue":"1","key":"e_1_2_10_32_1","first-page":"83","article-title":"Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus","volume":"15","author":"Miyazaki YGL","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0000000000000811"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201020870\u20101"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.517"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(20)32511\u20103"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23503"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab242"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T01:39:57Z","timestamp":1716860397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.3799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1002\/dmrr.3799"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.3799","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/DMRR.3799\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3799\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3799\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3799\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3799\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3799\/v2\/review1","asserted-by":"object"}]},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]},"assertion":[{"value":"2023-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3799"}}