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Subjects were categorised according to fasting plasma glucose levels &lt;100\u00a0mg\/dL (normoglycemia), \u2265100 and \u2264\u00a0125\u00a0mg\/dL (prediabetes), or \u2265126\u00a0mg\/dL and\/or antidiabetic treatment (T2DM). The association between MAFLD and glomerular hyperfiltration, defined as a de\u2010indexed eGFR above the age\u2010 and gender\u2010specific 95th percentile, was assessed by multivariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the whole study group, MAFLD prevalence averaged 19.3%. The prevalence progressively increased from 14.7% to 33.2% and to 48.9% in subjects with normoglycemia, prediabetes and T2DM, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 for trend). Adjusted odds ratio (95% CI) for the association between MAFLD and hyperfiltration was 9.06 (8.53\u20139.62) in the study group considered as a whole, and 8.60 (8.03\u20139.21), 9.52 (8.11\u201311.18) and 8.31 (6.70\u201310.30) in subjects with normoglycemia, prediabetes and T2DM considered separately. In stratified analyses, MAFLD amplified age\u2010dependent eGFR decline in all groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MAFLD prevalence increases across the glycaemic spectrum. MAFLD is significantly associated with hyperfiltration and amplifies the age\u2010related eGFR decline.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.3810","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T06:35:38Z","timestamp":1715927738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>MAFLD<\/scp> and glomerular hyperfiltration in subjects with normoglycemia<scp>,<\/scp> prediabetes and type 2 diabetes: A\u00a0cross\u2010sectional population study"],"prefix":"10.1002","volume":"40","author":[{"given":"Manuela","family":"Abbate","sequence":"first","affiliation":[{"name":"Research Group on Global Health University of the Balearic Islands  Palma Spain"},{"name":"Research Group on Evidence Lifestyles and Health Research Health Research Institute of the Balearic Islands (IdISBa)  Palma Spain"},{"name":"Nursing and Physiotherapy Department University of the Balearic Islands  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Research Institute of the Balearic Islands (IdISBa)  Palma Spain"},{"name":"Nursing and Physiotherapy Department University of the Balearic Islands  Palma Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-2141","authenticated-orcid":false,"given":"Miquel","family":"Bennasar\u2010Veny","sequence":"additional","affiliation":[{"name":"Research Group on Global Health University of the Balearic Islands  Palma Spain"},{"name":"Research Group on Evidence Lifestyles and Health Research Health Research Institute of the Balearic Islands (IdISBa)  Palma Spain"},{"name":"Nursing and Physiotherapy Department University of the Balearic Islands  Palma Spain"},{"name":"CIBER de Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6887-4562","authenticated-orcid":false,"given":"Jos\u00e9 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