{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:12Z","timestamp":1786977552461,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014690","name":"Ministerium f\u00fcr Kultur und Wissenschaft des Landes Nordrhein-Westfalen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003107","name":"Bundesministerium f\u00fcr Gesundheit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010215","name":"Deutsche Diabetes Gesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010215","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      We recently reported that genetic variability in the\n                      <jats:italic>TKT<\/jats:italic>\n                      gene encoding transketolase, a key enzyme in the pentose phosphate pathway, is associated with measures of diabetic sensorimotor polyneuropathy (DSPN) in recent\u2010onset diabetes. Here, we aimed to substantiate these findings in a population\u2010based KORA F4 study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this cross\u2010sectional study, we assessed seven single nucleotide polymorphisms (SNPs) in the transketolase gene in 952 participants from the KORA F4 study with normal glucose tolerance (NGT;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0394), prediabetes (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0411), and type 2 diabetes (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0147). DSPN was defined by the examination part\u00a0of the Michigan Neuropathy Screening Instrument (MNSI) using the original MNSI &gt; 2 cut\u2010off and two alternative versions extended by touch\/pressure perception (TPP) (MNSI\u00a0&gt;\u00a03) and by TPP plus cold perception (MNSI &gt; 4).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjustment for sex, age, BMI, and HbA1c, in type 2 diabetes participants, four out of seven transketolase SNPs were associated with DSPN for all three MNSI versions (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a00.004). The odds ratios of these associations increased with extending the MNSI score, for example, OR (95% CI) for SNP rs62255988 with MNSI\u00a0&gt;\u00a02: 1.99 (1.16\u20133.41), MNSI\u00a0&gt;\u00a03: 2.27 (1.26\u20134.09), and MNSI\u00a0&gt;\u00a04: 4.78 (2.22\u201310.26); SNP rs9284890 with MNSI\u00a0&gt;\u00a02: 2.43 (1.42\u20134.16), MNSI\u00a0&gt;\u00a03: 3.46 (1.82\u20136.59), and MNSI\u00a0&gt;\u00a04: 4.75 (2.15\u201310.51). In contrast, no associations were found between transketolase SNPs and the three MNSI versions in the NGT and prediabetes groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The link of genetic variation in transketolase enzyme to diabetic polyneuropathy corroborated at the population level strengthens the concept suggesting an important role of pathways metabolising glycolytic intermediates in the evolution of diabetic polyneuropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3834","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T01:50:02Z","timestamp":1720057802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of transketolase polymorphisms with diabetic polyneuropathy in the general population: The KORA F4 study"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8956-3552","authenticated-orcid":false,"given":"Dan","family":"Ziegler","sequence":"first","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Center Leibniz Center for Diabetes Research at Heinrich Heine University  D\u00fcsseldorf Germany"},{"name":"Department of Endocrinology and Diabetology Medical Faculty and University Hospital Heinrich Heine University  D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research (DZD) Partner D\u00fcsseldorf M\u00fcnchen\u2010Neuherberg  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Thorand","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health (GmbH)  Neuherberg Germany"},{"name":"German Center for Diabetes Research (DZD) Partner M\u00fcnchen\u2010Neuherberg  Neuherberg Germany"},{"name":"Faculty of Medicine Institute for Medical Information Processing Biometry and Epidemiology (IBE) LMU Munich Pettenkofer School of Public Health  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Strom","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Center Leibniz Center for Diabetes Research at Heinrich Heine University  D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research (DZD) Partner D\u00fcsseldorf M\u00fcnchen\u2010Neuherberg  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gidon J.","family":"B\u00f6nhof","sequence":"additional","affiliation":[{"name":"Institute for Clinical Diabetology German Diabetes Center Leibniz Center for Diabetes Research at Heinrich Heine University  D\u00fcsseldorf Germany"},{"name":"Department of Endocrinology and Diabetology Medical Faculty and University Hospital Heinrich Heine University  D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research (DZD) Partner D\u00fcsseldorf M\u00fcnchen\u2010Neuherberg  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Knebel","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD) Partner D\u00fcsseldorf M\u00fcnchen\u2010Neuherberg  Neuherberg Germany"},{"name":"Institute of Clinical Biochemistry and Pathobiochemistry German Diabetes Center Leibniz Center for Diabetes Research At Heinrich Heine University  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Schleicher","sequence":"additional","affiliation":[{"name":"German Centre for Diabetes Research (DZD) Helmholtz Centre Munich Partner T\u00fcbingen  Neuherberg Germany"},{"name":"Department for Diagnostic Laboratory Medicine Institute for Clinical Chemistry and Pathobiochemistry University Hospital 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