{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:11:16Z","timestamp":1785845476383,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002597","name":"Kyung Hee University","doi-asserted-by":"publisher","award":["KHU\u201020230913"],"award-info":[{"award-number":["KHU\u201020230913"]}],"id":[{"id":"10.13039\/501100002597","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The age\u2010standardised incidence ratio of gastrointestinal cancers in type 1 diabetes (T1D) patients has been reported to be higher than that in the general population. After adjusting for shared risk factors, we aimed to explore the association between T1D and gastrointestinal cancer and examine how this relationship varies by age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 268,179 participants from the Korean National Health Insurance Service\u2010National Sample Cohort. The primary outcome is the incident of gastrointestinal cancers, based on diagnostic codes. Multivariate Cox regression analyses were performed to assess the association between T1D and gastrointestinal cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 268,179 participants, 2681 had T1D at baseline and were followed for 12.98 (\u00b1 2.92) years. Compared with non\u2010T1D, T1D patients had a significantly increased risk of all gastrointestinal cancer (adjusted hazard ratio [aHR]: 1.403, 95% confidence interval [CI]: 1.253\u20131.573). T1D patients increased risks of oesophageal cancer (aHR: 1.864, 95% CI: 1.038\u20133.349), gastric cancer (aHR: 1.313, 95% CI: 1.066\u20131.616), colon cancer (aHR: 1.365, 95% CI: 1.110\u20131.678), liver cancer (aHR: 1.388, 95% CI: 1.115\u20131.727), and pancreatic cancer (aHR: 1.716, 95% CI: 1.182\u20132.492). The consistency of this association persisted among both male and female, with its strength increasing with older age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The risk of gastrointestinal cancer was significantly increased in T1D patients. Older male T1D patients exhibit a higher risk, suggesting the need for targeted attention in their care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.3848","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T03:44:16Z","timestamp":1728359056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association Between Type 1 Diabetes Mellitus and Incident Gastrointestinal Cancer in Korean Population: A Nationwide Retrospective Cohort Study"],"prefix":"10.1002","volume":"40","author":[{"given":"Soonsu","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine Graduate School Kyung Hee University  Seoul Korea"},{"name":"Department of Occupational and Environmental Medicine Kyung Hee University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Ewha Medical Data Organization Ewha Womans University Seoul Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Mo","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine School of Medicine Kyung Hee University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhee","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environment Medicine College of Medicine Ewha Womans University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-1426","authenticated-orcid":false,"given":"Jae\u2010Hong","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine School of Medicine Kyung Hee University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)31320\u20105"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(22)00218\u20102"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14\u20100096"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010015\u20103857\u20104"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010022\u201005659\u20109"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110580"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7607"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2020.09.023"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20\u20100204"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10\u20100666"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyy047"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.je20140197"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg105"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.07.017"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602611"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010016\u20103884\u20109"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.7110"},{"issue":"2","key":"e_1_2_10_19_1","first-page":"e15","article-title":"Cohort Profile: The National Health Insurance Service\u2013National Sample Cohort (NHIS\u2010NSC), South Korea","volume":"46","author":"Lee J.","year":"2016","journal-title":"International Journal of Epidemiology"},{"key":"e_1_2_10_20_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems, 10th Revision, Fifth Edition, 2016","author":"World Health Organization","year":"2015"},{"key":"e_1_2_10_21_1","volume-title":"The Asia\u2010Pacific Perspective: Redefining Obesity and its Treatment","author":"World Health Organization, Regional Office for the Western Pacific","year":"2000"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14\u20101996"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010021\u201005571\u20108"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010019\u20101309\u20106"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004\u201027302012000700006"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42269\u2010018\u20100016\u20103"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci31537"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.02.044"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2018.59.1.28"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34390"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34548"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100811"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa575"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.109827"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc24\u2010s004"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2017036"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010019\u201004995\u20107"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/cej.0000000000000165"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.2960"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112719"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/cd18\u20100088"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21\u20100770"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22170"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.001"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114519000424"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci21\u20100043"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2020.0212"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.3848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T01:23:27Z","timestamp":1734053007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.3848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/dmrr.3848"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.3848","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/DMRR.3848\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3848\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3848\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3848\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3848\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.3848\/v2\/review1","asserted-by":"object"}]},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e3848"}}