{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:29:43Z","timestamp":1773286183579,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,5,30]],"date-time":"2003-05-30T00:00:00Z","timestamp":1054252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the study was to compare the abnormalities in insulin secretion and insulin sensitivity in impaired fasting glucose (IFG) and in impaired glucose tolerance (IGT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Glucose tolerance was determined by oral glucose tolerance test in 289 non\u2010diabetic subjects selected for this study (M : F, 160 : 129, mean age 42.2 \u00b1 11.0 (SD) years, mean body mass index (BMI) 24.9 \u00b1 4.2 kg\/m<jats:sup>2<\/jats:sup>). Diabetic subjects were excluded from the study. The association of insulin resistance and \u03b2\u2010cell function (calculated by HOMA model) with IFG and IGT was studied using linear and multiple logistic regression analyses. Subjects with normoglycaemia (NGT) were used as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Insulin resistance was significantly more in IFG and in IGT than in NGT. \u03b2\u2010cell dysfunction was significantly higher in IFG than in IGT. IFG was associated with both insulin resistance (OR = 9.11, <jats:italic>p<\/jats:italic> &lt; 0.001) and \u03b2\u2010cell dysfunction (inverse correlation, OR = 0.103, <jats:italic>p<\/jats:italic> &lt; 0.001), while only insulin resistance was significantly associated with IGT (OR = 1.24, <jats:italic>p<\/jats:italic> = 0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In urban South Asian Indians, IFG differed from IGT in having combined insulin resistance and \u03b2\u2010cell dysfunction, while IGT was associated only with insulin resistance. 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