{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:51:12Z","timestamp":1776135072057,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,10,27]],"date-time":"2003-10-27T00:00:00Z","timestamp":1067212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Increased mortality in diabetic patients treated with combinations of high doses of sulfonylureas and metformin was recently reported. This study was aimed at the assessment of mortality in patients treated with low\u2010dose combinations of sulfonylureas and biguanides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational cohort study was performed on a consecutive series of 927 outpatients with type 2 diabetes mellitus. Of these patients, 376 were treated with combinations of sulfonylureas (mean daily dose \u00b1 SD: 7.3 \u00b1 3.2 mg for glibenclamide, and 338 \u00b1 79 mg for chlorpropamide) and biguanides (daily dose: 1.1 \u00b1 0.3 g for metformin, 60.1 \u00b1 19.6 mg for phenformin). Mortality was assessed through a search in the City of Florence Registry Office, with an average follow\u2010up of 55.1 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After adjusting for other potential confounders (including age, duration of diabetes, BMI, hypertension, lipid profile, HbA<jats:sub>1c<\/jats:sub>, and insulin treatment), mortality was significantly higher in patients treated with combinations of sulfonylureas and biguanides than in the rest of the sample, (relative risk, RR: 2.08; 95% confidence interval, CI 1.18\u20133.67, and RR: 1.68; 95%CI 1.01\u20132.79 among women and men, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A higher mortality was observed in patients treated with combinations of sulfonylureas and biguanides, even at low doses. Safety of such combinations deserves further investigation. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.411","type":"journal-article","created":{"date-parts":[[2004,1,19]],"date-time":"2004-01-19T08:01:14Z","timestamp":1074499274000},"page":"44-47","source":"Crossref","is-referenced-by-count":49,"title":["All\u2010cause mortality in diabetic patients treated with combinations of sulfonylureas and biguanides"],"prefix":"10.1002","volume":"20","author":[{"given":"Edoardo","family":"Mannucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Monami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"Masotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccol\u00f2","family":"Marchionni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,10,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07037-8"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960240210"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051343"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.8.6.562"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641969909061028"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(69)80120-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.21.9.976"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020904"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70038-4"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.3.808"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdmrr.411","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T22:11:37Z","timestamp":1697062297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,27]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1002\/dmrr.411"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.411","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,27]]}}}